| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADCYAP1 | CPAMD8 | ENSP00000411658 | ENSP00000402505 | adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | 0.576 |
| ADCYAP1 | DPP4 | ENSP00000411658 | ENSP00000353731 | adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | 0.491 |
| ADCYAP1 | SCTR | ENSP00000411658 | ENSP00000019103 | adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells | secretin receptor; This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.995 |
| CPAMD8 | ADCYAP1 | ENSP00000402505 | ENSP00000411658 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells | 0.576 |
| CPAMD8 | DPP4 | ENSP00000402505 | ENSP00000353731 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | 0.576 |
| CPAMD8 | FURIN | ENSP00000402505 | ENSP00000268171 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | 0.606 |
| CPAMD8 | GUCY1A2 | ENSP00000402505 | ENSP00000431245 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | 0.485 |
| CPAMD8 | NTNG1 | ENSP00000402505 | ENSP00000359085 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.470 |
| CPAMD8 | SCTR | ENSP00000402505 | ENSP00000019103 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | secretin receptor; This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.576 |
| CPAMD8 | SH3TC1 | ENSP00000402505 | ENSP00000245105 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | SH3 domain and tetratricopeptide repeats 1 | 0.580 |
| CPAMD8 | STARD8 | ENSP00000402505 | ENSP00000363727 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | StAR-related lipid transfer (START) domain containing 8; Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1 | 0.478 |
| CPAMD8 | ZNF569 | ENSP00000402505 | ENSP00000325018 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | zinc finger protein 569; May be involved in transcriptional regulation (By similarity) | 0.531 |
| CPAMD8 | ZNF777 | ENSP00000402505 | ENSP00000247930 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | zinc finger protein 777; May be involved in transcriptional regulation | 0.561 |
| DPP4 | ADCYAP1 | ENSP00000353731 | ENSP00000411658 | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells | 0.491 |
| DPP4 | CPAMD8 | ENSP00000353731 | ENSP00000402505 | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | 0.576 |
| DPP4 | FURIN | ENSP00000353731 | ENSP00000268171 | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | 0.620 |
| FURIN | CPAMD8 | ENSP00000268171 | ENSP00000402505 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | 0.606 |
| FURIN | DPP4 | ENSP00000268171 | ENSP00000353731 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | dipeptidyl-peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and in [...] | 0.620 |
| GUCY1A2 | CPAMD8 | ENSP00000431245 | ENSP00000402505 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | 0.485 |
| GUCY1A2 | NTNG1 | ENSP00000431245 | ENSP00000359085 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.484 |
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