Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
SYNJ2 SYNJ2 SYNJ1 SYNJ1 TPTE2 TPTE2 ARHGAP11B ARHGAP11B MTMR10 MTMR10 GREM1 GREM1 FAN1 FAN1 EVC EVC TRPM1 TRPM1 IFT80 IFT80 DYNC2H1 DYNC2H1
"MTMR10" - myotubularin related protein 10 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTMR10myotubularin related protein 10; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) (777 aa)    
Predicted Functional Partners:
FAN1
FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] (1017 aa)
            score_image   0.811
TRPM1
transient receptor potential cation channel, subfamily M, member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel (1603 aa)
            score_image   0.778
SYNJ1
synaptojanin 1; Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis (1612 aa)
        score_image   score_image   0.724
SYNJ2
synaptojanin 2; Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis (1496 aa)
        score_image   score_image   0.724
IFT80
intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia (777 aa)
            score_image   0.690
EVC
Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) (992 aa)
            score_image   0.667
DYNC2H1
dynein, cytoplasmic 2, heavy chain 1 (4314 aa)
            score_image   0.609
ARHGAP11B
Rho GTPase activating protein 11B (267 aa)
        score_image   score_image   0.608
GREM1
gremlin 1; Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity) (184 aa)
            score_image   0.590
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 (522 aa)
        score_image   score_image   0.589
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (29%)