node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP11B | FAN1 | ENSP00000392760 | ENSP00000354497 | Rho GTPase activating protein 11B | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | 0.422 |
ARHGAP11B | MTMR10 | ENSP00000392760 | ENSP00000402537 | Rho GTPase activating protein 11B | myotubularin related protein 10; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | 0.608 |
DYNC2H1 | EVC | ENSP00000381167 | ENSP00000264956 | dynein, cytoplasmic 2, heavy chain 1 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | 0.510 |
DYNC2H1 | FAN1 | ENSP00000381167 | ENSP00000354497 | dynein, cytoplasmic 2, heavy chain 1 | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | 0.517 |
DYNC2H1 | IFT80 | ENSP00000381167 | ENSP00000312778 | dynein, cytoplasmic 2, heavy chain 1 | intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia | 0.866 |
DYNC2H1 | MTMR10 | ENSP00000381167 | ENSP00000402537 | dynein, cytoplasmic 2, heavy chain 1 | myotubularin related protein 10; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | 0.609 |
DYNC2H1 | TRPM1 | ENSP00000381167 | ENSP00000380897 | dynein, cytoplasmic 2, heavy chain 1 | transient receptor potential cation channel, subfamily M, member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel | 0.400 |
EVC | DYNC2H1 | ENSP00000264956 | ENSP00000381167 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | dynein, cytoplasmic 2, heavy chain 1 | 0.510 |
EVC | FAN1 | ENSP00000264956 | ENSP00000354497 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | 0.606 |
EVC | IFT80 | ENSP00000264956 | ENSP00000312778 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia | 0.476 |
EVC | MTMR10 | ENSP00000264956 | ENSP00000402537 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | myotubularin related protein 10; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | 0.667 |
EVC | TRPM1 | ENSP00000264956 | ENSP00000380897 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | transient receptor potential cation channel, subfamily M, member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel | 0.440 |
FAN1 | ARHGAP11B | ENSP00000354497 | ENSP00000392760 | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | Rho GTPase activating protein 11B | 0.422 |
FAN1 | DYNC2H1 | ENSP00000354497 | ENSP00000381167 | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | dynein, cytoplasmic 2, heavy chain 1 | 0.517 |
FAN1 | EVC | ENSP00000354497 | ENSP00000264956 | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | 0.606 |
FAN1 | GREM1 | ENSP00000354497 | ENSP00000300177 | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | gremlin 1; Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity) | 0.489 |
FAN1 | IFT80 | ENSP00000354497 | ENSP00000312778 | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia | 0.610 |
FAN1 | MTMR10 | ENSP00000354497 | ENSP00000402537 | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | myotubularin related protein 10; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | 0.811 |
FAN1 | TRPM1 | ENSP00000354497 | ENSP00000380897 | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | transient receptor potential cation channel, subfamily M, member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel | 0.682 |
GREM1 | FAN1 | ENSP00000300177 | ENSP00000354497 | gremlin 1; Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity) | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | 0.489 |