MDGA1 protein (Homo sapiens) - STRING network view

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MDGA1

MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity) (955 aa)

Predicted Functional Partners:

IGSF9B

0.923

ENSG00000212857

0.457

LIN7A

0.456

FREM3

0.429

EIF2A

0.412

FAM102A

0.403

FAM102B

0.403

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2A	ENSG00000212857	ENSP00000417229	ENSP00000375387	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	Uncharacterized protein DKFZp434B061	0.568
EIF2A	FREM3	ENSP00000417229	ENSP00000332886	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity)	0.502
EIF2A	MDGA1	ENSP00000417229	ENSP00000402584	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	0.412
ENSG00000212857	EIF2A	ENSP00000375387	ENSP00000417229	Uncharacterized protein DKFZp434B061	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	0.568
ENSG00000212857	FREM3	ENSP00000375387	ENSP00000332886	Uncharacterized protein DKFZp434B061	FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity)	0.508
ENSG00000212857	MDGA1	ENSP00000375387	ENSP00000402584	Uncharacterized protein DKFZp434B061	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	0.457
FAM102A	MDGA1	ENSP00000362187	ENSP00000402584	family with sequence similarity 102, member A; May play a role in estrogen action	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	0.403
FAM102B	MDGA1	ENSP00000359052	ENSP00000402584	family with sequence similarity 102, member B	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	0.403
FREM3	EIF2A	ENSP00000332886	ENSP00000417229	FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity)	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	0.502
FREM3	ENSG00000212857	ENSP00000332886	ENSP00000375387	FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity)	Uncharacterized protein DKFZp434B061	0.508
FREM3	MDGA1	ENSP00000332886	ENSP00000402584	FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity)	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	0.429
IGSF9B	MDGA1	ENSP00000317980	ENSP00000402584	immunoglobulin superfamily, member 9B	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	0.923
LIN7A	MDGA1	ENSP00000447488	ENSP00000402584	lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	0.456
MDGA1	EIF2A	ENSP00000402584	ENSP00000417229	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins	0.412
MDGA1	ENSG00000212857	ENSP00000402584	ENSP00000375387	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	Uncharacterized protein DKFZp434B061	0.457
MDGA1	FAM102A	ENSP00000402584	ENSP00000362187	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	family with sequence similarity 102, member A; May play a role in estrogen action	0.403
MDGA1	FAM102B	ENSP00000402584	ENSP00000359052	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	family with sequence similarity 102, member B	0.403
MDGA1	FREM3	ENSP00000402584	ENSP00000332886	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity)	0.429
MDGA1	IGSF9B	ENSP00000402584	ENSP00000317980	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	immunoglobulin superfamily, member 9B	0.923
MDGA1	LIN7A	ENSP00000402584	ENSP00000447488	MAM domain containing glycosylphosphatidylinositol anchor 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity)	lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	0.456

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