| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGAP6 | TREML1 | ENSP00000363168 | ENSP00000402855 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 6; Putative GTPase-activating protein (Potential) | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | 0.625 |
| AGAP8 | TREML1 | ENSP00000415452 | ENSP00000402855 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 8; Putative GTPase-activating protein (Potential) | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | 0.625 |
| EZR | SELP | ENSP00000338934 | ENSP00000263686 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | selectin P (granule membrane protein 140kDa, antigen CD62); Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1 | 0.642 |
| EZR | TREML1 | ENSP00000338934 | ENSP00000402855 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | 0.800 |
| NCR2 | TREML1 | ENSP00000362181 | ENSP00000402855 | natural cytotoxicity triggering receptor 2; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | 0.518 |
| PTPN11 | PTPN6 | ENSP00000340944 | ENSP00000391592 | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis | 0.582 |
| PTPN11 | TREML1 | ENSP00000340944 | ENSP00000402855 | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | 0.732 |
| PTPN6 | PTPN11 | ENSP00000391592 | ENSP00000340944 | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.582 |
| PTPN6 | TREML1 | ENSP00000391592 | ENSP00000402855 | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | 0.576 |
| SELP | EZR | ENSP00000263686 | ENSP00000338934 | selectin P (granule membrane protein 140kDa, antigen CD62); Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | 0.642 |
| SELP | TREML1 | ENSP00000263686 | ENSP00000402855 | selectin P (granule membrane protein 140kDa, antigen CD62); Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1 | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | 0.608 |
| TREM1 | TREM2 | ENSP00000244709 | ENSP00000362205 | triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock | triggering receptor expressed on myeloid cells 2; May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells | 0.863 |
| TREM1 | TREML1 | ENSP00000244709 | ENSP00000402855 | triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | 0.754 |
| TREM1 | TREML2 | ENSP00000244709 | ENSP00000418767 | triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock | triggering receptor expressed on myeloid cells-like 2; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation | 0.800 |
| TREM2 | TREM1 | ENSP00000362205 | ENSP00000244709 | triggering receptor expressed on myeloid cells 2; May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells | triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock | 0.863 |
| TREM2 | TREML1 | ENSP00000362205 | ENSP00000402855 | triggering receptor expressed on myeloid cells 2; May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | 0.751 |
| TREM2 | TREML2 | ENSP00000362205 | ENSP00000418767 | triggering receptor expressed on myeloid cells 2; May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells | triggering receptor expressed on myeloid cells-like 2; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation | 0.759 |
| TREML1 | AGAP6 | ENSP00000402855 | ENSP00000363168 | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | ArfGAP with GTPase domain, ankyrin repeat and PH domain 6; Putative GTPase-activating protein (Potential) | 0.625 |
| TREML1 | AGAP8 | ENSP00000402855 | ENSP00000415452 | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | ArfGAP with GTPase domain, ankyrin repeat and PH domain 8; Putative GTPase-activating protein (Potential) | 0.625 |
| TREML1 | EZR | ENSP00000402855 | ENSP00000338934 | triggering receptor expressed on myeloid cells-like 1; Cell surface receptor that may play a role in the innate and adaptive immune response | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | 0.800 |
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