| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FBP1 | FBP2 | ENSP00000364475 | ENSP00000364486 | fructose-1,6-bisphosphatase 1 | fructose-1,6-bisphosphatase 2 | 0.821 |
| FBP1 | GCK | ENSP00000364475 | ENSP00000223366 | fructose-1,6-bisphosphatase 1 | glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage | 0.715 |
| FBP1 | PFKL | ENSP00000364475 | ENSP00000269848 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.831 |
| FBP1 | PFKM | ENSP00000364475 | ENSP00000345771 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.830 |
| FBP1 | PRF1 | ENSP00000364475 | ENSP00000316746 | fructose-1,6-bisphosphatase 1 | perforin 1 (pore forming protein); Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes | 0.404 |
| FBP1 | ZBTB22 | ENSP00000364475 | ENSP00000404403 | fructose-1,6-bisphosphatase 1 | zinc finger and BTB domain containing 22; May be involved in transcriptional regulation | 0.673 |
| FBP2 | FBP1 | ENSP00000364486 | ENSP00000364475 | fructose-1,6-bisphosphatase 2 | fructose-1,6-bisphosphatase 1 | 0.821 |
| FBP2 | GCK | ENSP00000364486 | ENSP00000223366 | fructose-1,6-bisphosphatase 2 | glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage | 0.720 |
| FBP2 | PFKL | ENSP00000364486 | ENSP00000269848 | fructose-1,6-bisphosphatase 2 | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.861 |
| FBP2 | PFKM | ENSP00000364486 | ENSP00000345771 | fructose-1,6-bisphosphatase 2 | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.854 |
| FBP2 | PRF1 | ENSP00000364486 | ENSP00000316746 | fructose-1,6-bisphosphatase 2 | perforin 1 (pore forming protein); Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes | 0.472 |
| FBP2 | ZBTB22 | ENSP00000364486 | ENSP00000404403 | fructose-1,6-bisphosphatase 2 | zinc finger and BTB domain containing 22; May be involved in transcriptional regulation | 0.790 |
| GCK | FBP1 | ENSP00000223366 | ENSP00000364475 | glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage | fructose-1,6-bisphosphatase 1 | 0.715 |
| GCK | FBP2 | ENSP00000223366 | ENSP00000364486 | glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage | fructose-1,6-bisphosphatase 2 | 0.720 |
| GCK | PFKL | ENSP00000223366 | ENSP00000269848 | glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.839 |
| GCK | PFKM | ENSP00000223366 | ENSP00000345771 | glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.869 |
| GCK | WDTC1 | ENSP00000223366 | ENSP00000355317 | glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage | WD and tetratricopeptide repeats 1 | 0.682 |
| GCK | ZBTB22 | ENSP00000223366 | ENSP00000404403 | glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage | zinc finger and BTB domain containing 22; May be involved in transcriptional regulation | 0.571 |
| KDELR1 | KDELR2 | ENSP00000329471 | ENSP00000258739 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | 0.901 |
| KDELR1 | ZBTB22 | ENSP00000329471 | ENSP00000404403 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | zinc finger and BTB domain containing 22; May be involved in transcriptional regulation | 0.660 |
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