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STRINGSTRING
MCMBP MCMBP GSG1 GSG1 COL18A1 COL18A1 TECPR1 TECPR1 ATG12 ATG12 TRAPPC12 TRAPPC12 WIPI2 WIPI2 WIPI1 WIPI1 ATG5 ATG5 TRAPPC8 TRAPPC8 TRAPPC11 TRAPPC11
"TECPR1" - tectonin beta-propeller repeat containing 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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TECPR1tectonin beta-propeller repeat containing 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes- acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (1165 aa)    
Predicted Functional Partners:
ATG12
autophagy related 12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct associ [...] (140 aa)
        score_image   score_image   0.986
ATG5
autophagy related 5; Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity) (275 aa)
        score_image   score_image   0.966
WIPI2
WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P (454 aa)
            score_image   0.914
TRAPPC12
trafficking protein particle complex 12; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (735 aa)
        score_image   score_image   0.771
TRAPPC8
trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (1435 aa)
        score_image   score_image   0.749
TRAPPC11
trafficking protein particle complex 11 (1133 aa)
        score_image   score_image   0.721
WIPI1
WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...] (446 aa)
            score_image   0.686
GSG1
germ cell associated 1; May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum (By similarity) (339 aa)
        score_image       0.657
MCMBP
minichromosome maintenance complex binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (642 aa)
        score_image       0.657
COL18A1
collagen, type XVIII, alpha 1 (1519 aa)
        score_image       0.657
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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