SH2D5 protein (Homo sapiens) - STRING network view

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SH2D5

SH2 domain containing 5 (423 aa)

Predicted Functional Partners:

TMCO4

0.703

GRB2

0.629

INPPL1

0.566

PLA2G2E

0.539

RNF186

0.536

FAM163B

0.503

SNRNP35

0.470

SYNDIG1L

0.457

PLA2G2F

0.435

SLC2A4

0.418

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM163B	SH2D5	ENSP00000349336	ENSP00000406026	family with sequence similarity 163, member B	SH2 domain containing 5	0.503
FAM163B	SYNDIG1L	ENSP00000349336	ENSP00000331474	family with sequence similarity 163, member B	synapse differentiation inducing 1-like	0.649
GRB2	INPPL1	ENSP00000339007	ENSP00000298229	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...]	0.758
GRB2	SH2D5	ENSP00000339007	ENSP00000406026	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	SH2 domain containing 5	0.629
GRB2	SLC2A4	ENSP00000339007	ENSP00000320935	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter	0.595
INPPL1	GRB2	ENSP00000298229	ENSP00000339007	inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...]	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	0.758
INPPL1	SH2D5	ENSP00000298229	ENSP00000406026	inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...]	SH2 domain containing 5	0.566
INPPL1	SLC2A4	ENSP00000298229	ENSP00000320935	inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...]	solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter	0.547
PLA2G2E	RNF186	ENSP00000364257	ENSP00000364263	phospholipase A2, group IIE; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids	ring finger protein 186	0.422
PLA2G2E	SH2D5	ENSP00000364257	ENSP00000406026	phospholipase A2, group IIE; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids	SH2 domain containing 5	0.539
PLA2G2E	TMCO4	ENSP00000364257	ENSP00000294543	phospholipase A2, group IIE; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids	transmembrane and coiled-coil domains 4	0.570
PLA2G2F	SH2D5	ENSP00000364243	ENSP00000406026	phospholipase A2, group IIF; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference	SH2 domain containing 5	0.435
PLA2G2F	TMCO4	ENSP00000364243	ENSP00000294543	phospholipase A2, group IIF; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference	transmembrane and coiled-coil domains 4	0.588
RNF186	PLA2G2E	ENSP00000364263	ENSP00000364257	ring finger protein 186	phospholipase A2, group IIE; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids	0.422
RNF186	SH2D5	ENSP00000364263	ENSP00000406026	ring finger protein 186	SH2 domain containing 5	0.536
RNF186	TMCO4	ENSP00000364263	ENSP00000294543	ring finger protein 186	transmembrane and coiled-coil domains 4	0.486
SH2D5	FAM163B	ENSP00000406026	ENSP00000349336	SH2 domain containing 5	family with sequence similarity 163, member B	0.503
SH2D5	GRB2	ENSP00000406026	ENSP00000339007	SH2 domain containing 5	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	0.629
SH2D5	INPPL1	ENSP00000406026	ENSP00000298229	SH2 domain containing 5	inositol polyphosphate phosphatase-like 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 traf [...]	0.566
SH2D5	PLA2G2E	ENSP00000406026	ENSP00000364257	SH2 domain containing 5	phospholipase A2, group IIE; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids	0.539

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