node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf50 | EPM2AIP1 | ENSP00000361603 | ENSP00000406027 | chromosome 1 open reading frame 50 | EPM2A (laforin) interacting protein 1 | 0.475 |
C1orf50 | UBC | ENSP00000361603 | ENSP00000344818 | chromosome 1 open reading frame 50 | ubiquitin C | 0.483 |
CSNK1A1 | EPM2AIP1 | ENSP00000421689 | ENSP00000406027 | casein kinase 1, alpha 1 | EPM2A (laforin) interacting protein 1 | 0.515 |
CSNK1A1 | UBC | ENSP00000421689 | ENSP00000344818 | casein kinase 1, alpha 1 | ubiquitin C | 0.948 |
EMP2 | EPM2AIP1 | ENSP00000352540 | ENSP00000406027 | epithelial membrane protein 2 | EPM2A (laforin) interacting protein 1 | 0.576 |
EPM2A | EPM2AIP1 | ENSP00000356489 | ENSP00000406027 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | EPM2A (laforin) interacting protein 1 | 0.854 |
EPM2A | NFU1 | ENSP00000356489 | ENSP00000387219 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae); Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins | 0.947 |
EPM2A | PPP1R3C | ENSP00000356489 | ENSP00000238994 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | 0.994 |
EPM2A | TXNL1 | ENSP00000356489 | ENSP00000217515 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | thioredoxin-like 1; Active thioredoxin with a redox potential of about -250 mV | 0.750 |
EPM2A | UBC | ENSP00000356489 | ENSP00000344818 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | ubiquitin C | 0.981 |
EPM2AIP1 | C1orf50 | ENSP00000406027 | ENSP00000361603 | EPM2A (laforin) interacting protein 1 | chromosome 1 open reading frame 50 | 0.475 |
EPM2AIP1 | CSNK1A1 | ENSP00000406027 | ENSP00000421689 | EPM2A (laforin) interacting protein 1 | casein kinase 1, alpha 1 | 0.515 |
EPM2AIP1 | EMP2 | ENSP00000406027 | ENSP00000352540 | EPM2A (laforin) interacting protein 1 | epithelial membrane protein 2 | 0.576 |
EPM2AIP1 | EPM2A | ENSP00000406027 | ENSP00000356489 | EPM2A (laforin) interacting protein 1 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | 0.854 |
EPM2AIP1 | MLH1 | ENSP00000406027 | ENSP00000231790 | EPM2A (laforin) interacting protein 1 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | 0.480 |
EPM2AIP1 | NFU1 | ENSP00000406027 | ENSP00000387219 | EPM2A (laforin) interacting protein 1 | NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae); Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins | 0.607 |
EPM2AIP1 | PPP1R3C | ENSP00000406027 | ENSP00000238994 | EPM2A (laforin) interacting protein 1 | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | 0.563 |
EPM2AIP1 | SERPINF1 | ENSP00000406027 | ENSP00000254722 | EPM2A (laforin) interacting protein 1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity | 0.597 |
EPM2AIP1 | TXNL1 | ENSP00000406027 | ENSP00000217515 | EPM2A (laforin) interacting protein 1 | thioredoxin-like 1; Active thioredoxin with a redox potential of about -250 mV | 0.515 |
EPM2AIP1 | UBC | ENSP00000406027 | ENSP00000344818 | EPM2A (laforin) interacting protein 1 | ubiquitin C | 0.730 |