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STRINGSTRING
SERPINF1 SERPINF1 EMP2 EMP2 EPM2AIP1 EPM2AIP1 CSNK1A1 CSNK1A1 C1orf50 C1orf50 EPM2A EPM2A NFU1 NFU1 UBC UBC PPP1R3C PPP1R3C TXNL1 TXNL1 MLH1 MLH1
"EPM2AIP1" - EPM2A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EPM2AIP1EPM2A (laforin) interacting protein 1 (607 aa)    
Predicted Functional Partners:
EPM2A
epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) (331 aa)
        score_image   score_image   0.854
UBC
ubiquitin C (685 aa)
        score_image       0.730
NFU1
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae); Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins (254 aa)
            score_image   0.607
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (418 aa)
        score_image       0.597
EMP2
epithelial membrane protein 2 (167 aa)
        score_image       0.576
PPP1R3C
protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types (317 aa)
            score_image   0.563
CSNK1A1
casein kinase 1, alpha 1 (365 aa)
        score_image       0.515
TXNL1
thioredoxin-like 1; Active thioredoxin with a redox potential of about -250 mV (289 aa)
            score_image   0.515
MLH1
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] (756 aa)
            score_image   0.480
C1orf50
chromosome 1 open reading frame 50 (199 aa)
        score_image       0.475
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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