| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AK8 | CKMT1A | ENSP00000298545 | ENSP00000406577 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | 0.757 |
| AK8 | GOT1 | ENSP00000298545 | ENSP00000359539 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.532 |
| AK8 | LDHA | ENSP00000298545 | ENSP00000445175 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | lactate dehydrogenase A | 0.635 |
| AK8 | LDHB | ENSP00000298545 | ENSP00000229319 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | lactate dehydrogenase B | 0.652 |
| AK8 | LDHC | ENSP00000298545 | ENSP00000280704 | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | lactate dehydrogenase C; Possible role in sperm motility | 0.684 |
| CATSPER2 | CKMT1A | ENSP00000299989 | ENSP00000406577 | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | 0.860 |
| CATSPER2 | PPIP5K1 | ENSP00000299989 | ENSP00000380129 | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | diphosphoinositol pentakisphosphate kinase 1 | 0.819 |
| CATSPER2 | STRC | ENSP00000299989 | ENSP00000401513 | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia (By similarity) | 0.884 |
| CKMT1A | AK8 | ENSP00000406577 | ENSP00000298545 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | adenylate kinase 8; Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP | 0.757 |
| CKMT1A | CATSPER2 | ENSP00000406577 | ENSP00000299989 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | 0.860 |
| CKMT1A | CLPB | ENSP00000406577 | ENSP00000294053 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | 0.777 |
| CKMT1A | GAMT | ENSP00000406577 | ENSP00000403536 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | guanidinoacetate N-methyltransferase | 0.926 |
| CKMT1A | GOT1 | ENSP00000406577 | ENSP00000359539 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.757 |
| CKMT1A | LDHA | ENSP00000406577 | ENSP00000445175 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | lactate dehydrogenase A | 0.780 |
| CKMT1A | LDHB | ENSP00000406577 | ENSP00000229319 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | lactate dehydrogenase B | 0.814 |
| CKMT1A | LDHC | ENSP00000406577 | ENSP00000280704 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | lactate dehydrogenase C; Possible role in sperm motility | 0.815 |
| CKMT1A | PPIP5K1 | ENSP00000406577 | ENSP00000380129 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | diphosphoinositol pentakisphosphate kinase 1 | 0.801 |
| CKMT1A | STRC | ENSP00000406577 | ENSP00000401513 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia (By similarity) | 0.860 |
| CLPB | CKMT1A | ENSP00000294053 | ENSP00000406577 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | 0.777 |
| GAMT | CKMT1A | ENSP00000403536 | ENSP00000406577 | guanidinoacetate N-methyltransferase | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | 0.926 |
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