TMEM41A protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TMEM41A

transmembrane protein 41A (264 aa)

Predicted Functional Partners:

SEC11C

0.639

TAPBPL

0.639

MAP3K13

0.616

METTL7A

0.593

TMEM199

0.565

NCEH1

0.510

MARCH5

0.507

TMEM209

0.499

ENSG00000259024

0.491

FAM18B1

0.491

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSG00000259024	TMEM41A	ENSP00000429865	ENSP00000406885	FAM18B2-CDRT4 readthrough	transmembrane protein 41A	0.491
FAM18B1	TMEM41A	ENSP00000305654	ENSP00000406885	family with sequence similarity 18, member B1	transmembrane protein 41A	0.491
MAP3K13	TMEM41A	ENSP00000265026	ENSP00000406885	mitogen-activated protein kinase kinase kinase 13	transmembrane protein 41A	0.616
MARCH5	TMEM41A	ENSP00000351813	ENSP00000406885	membrane-associated ring finger (C3HC4) 5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1	transmembrane protein 41A	0.507
METTL7A	SEC11C	ENSP00000331787	ENSP00000468633	methyltransferase like 7A; Probable methyltransferase (By similarity)	SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.507
METTL7A	TAPBPL	ENSP00000331787	ENSP00000266556	methyltransferase like 7A; Probable methyltransferase (By similarity)	TAP binding protein-like	0.491
METTL7A	TMEM41A	ENSP00000331787	ENSP00000406885	methyltransferase like 7A; Probable methyltransferase (By similarity)	transmembrane protein 41A	0.593
NCEH1	SEC11C	ENSP00000442464	ENSP00000468633	neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration	SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.470
NCEH1	TAPBPL	ENSP00000442464	ENSP00000266556	neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration	TAP binding protein-like	0.436
NCEH1	TMEM41A	ENSP00000442464	ENSP00000406885	neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration	transmembrane protein 41A	0.510
SEC11C	METTL7A	ENSP00000468633	ENSP00000331787	SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	methyltransferase like 7A; Probable methyltransferase (By similarity)	0.507
SEC11C	NCEH1	ENSP00000468633	ENSP00000442464	SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration	0.470
SEC11C	TAPBPL	ENSP00000468633	ENSP00000266556	SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	TAP binding protein-like	0.491
SEC11C	TMEM41A	ENSP00000468633	ENSP00000406885	SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	transmembrane protein 41A	0.639
TAPBPL	METTL7A	ENSP00000266556	ENSP00000331787	TAP binding protein-like	methyltransferase like 7A; Probable methyltransferase (By similarity)	0.491
TAPBPL	NCEH1	ENSP00000266556	ENSP00000442464	TAP binding protein-like	neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration	0.436
TAPBPL	SEC11C	ENSP00000266556	ENSP00000468633	TAP binding protein-like	SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.491
TAPBPL	TMEM199	ENSP00000266556	ENSP00000292114	TAP binding protein-like	transmembrane protein 199	0.407
TAPBPL	TMEM41A	ENSP00000266556	ENSP00000406885	TAP binding protein-like	transmembrane protein 41A	0.639
TMEM199	TAPBPL	ENSP00000292114	ENSP00000266556	transmembrane protein 199	TAP binding protein-like	0.407

page 1 of 2

Textmining

Cooccurrence

Coexpression

Neighborhood

Experiments

Fusion

Databases

© STRING Consortium 2017

Credits

Access

Info

About