C4orf26 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

C4orf26

chromosome 4 open reading frame 26; Might promote nucleation of hydroxyapatite (176 aa)

Predicted Functional Partners:

FAM83H

0.568

MMP20

0.508

ENAM

0.506

AMELX

0.503

WDR72

0.499

AMELY

0.450

SLC24A4

0.412

AMBN

0.406

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBN	AMELX	ENSP00000313809	ENSP00000370088	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.811
AMBN	AMELY	ENSP00000313809	ENSP00000215479	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	amelogenin, Y-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.503
AMBN	C4orf26	ENSP00000313809	ENSP00000406925	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	chromosome 4 open reading frame 26; Might promote nucleation of hydroxyapatite	0.406
AMBN	ENAM	ENSP00000313809	ENSP00000379383	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.901
AMBN	FAM83H	ENSP00000313809	ENSP00000373565	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	family with sequence similarity 83, member H; May play a major role in the structural organization and calcification of developing enamel	0.507
AMBN	MMP20	ENSP00000313809	ENSP00000260228	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation	0.870
AMBN	WDR72	ENSP00000313809	ENSP00000353699	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	WD repeat domain 72	0.503
AMELX	AMBN	ENSP00000370088	ENSP00000313809	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	0.811
AMELX	C4orf26	ENSP00000370088	ENSP00000406925	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	chromosome 4 open reading frame 26; Might promote nucleation of hydroxyapatite	0.503
AMELX	ENAM	ENSP00000370088	ENSP00000379383	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.861
AMELX	FAM83H	ENSP00000370088	ENSP00000373565	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	family with sequence similarity 83, member H; May play a major role in the structural organization and calcification of developing enamel	0.566
AMELX	MMP20	ENSP00000370088	ENSP00000260228	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation	0.724
AMELX	WDR72	ENSP00000370088	ENSP00000353699	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	WD repeat domain 72	0.583
AMELY	AMBN	ENSP00000215479	ENSP00000313809	amelogenin, Y-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	0.503
AMELY	C4orf26	ENSP00000215479	ENSP00000406925	amelogenin, Y-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	chromosome 4 open reading frame 26; Might promote nucleation of hydroxyapatite	0.450
C4orf26	AMBN	ENSP00000406925	ENSP00000313809	chromosome 4 open reading frame 26; Might promote nucleation of hydroxyapatite	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	0.406
C4orf26	AMELX	ENSP00000406925	ENSP00000370088	chromosome 4 open reading frame 26; Might promote nucleation of hydroxyapatite	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.503
C4orf26	AMELY	ENSP00000406925	ENSP00000215479	chromosome 4 open reading frame 26; Might promote nucleation of hydroxyapatite	amelogenin, Y-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.450
C4orf26	ENAM	ENSP00000406925	ENSP00000379383	chromosome 4 open reading frame 26; Might promote nucleation of hydroxyapatite	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.506
C4orf26	FAM83H	ENSP00000406925	ENSP00000373565	chromosome 4 open reading frame 26; Might promote nucleation of hydroxyapatite	family with sequence similarity 83, member H; May play a major role in the structural organization and calcification of developing enamel	0.568

page 1 of 3

Textmining

Cooccurrence

Experiments

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About