| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AASS | LAX1 | ENSP00000377040 | ENSP00000406970 | aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | 0.681 |
| AASS | SCCPDH | ENSP00000377040 | ENSP00000355467 | aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively | saccharopine dehydrogenase (putative) | 0.910 |
| ALDH18A1 | LAX1 | ENSP00000360268 | ENSP00000406970 | aldehyde dehydrogenase 18 family, member A1 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | 0.748 |
| COL12A1 | COL19A1 | ENSP00000325146 | ENSP00000316030 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | collagen, type XIX, alpha 1 | 0.929 |
| COL12A1 | LAX1 | ENSP00000325146 | ENSP00000406970 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | 0.652 |
| COL19A1 | COL12A1 | ENSP00000316030 | ENSP00000325146 | collagen, type XIX, alpha 1 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | 0.929 |
| COL19A1 | LAX1 | ENSP00000316030 | ENSP00000406970 | collagen, type XIX, alpha 1 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | 0.669 |
| COMP | LAX1 | ENSP00000222271 | ENSP00000406970 | cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | 0.748 |
| GRAP2 | LAX1 | ENSP00000339186 | ENSP00000406970 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | 0.701 |
| GRAP2 | LCK | ENSP00000339186 | ENSP00000337825 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | lymphocyte-specific protein tyrosine kinase | 0.945 |
| GRAP2 | SYK | ENSP00000339186 | ENSP00000364898 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.983 |
| GRB2 | LAX1 | ENSP00000339007 | ENSP00000406970 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | 0.623 |
| GRB2 | LCK | ENSP00000339007 | ENSP00000337825 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | lymphocyte-specific protein tyrosine kinase | 0.942 |
| GRB2 | SYK | ENSP00000339007 | ENSP00000364898 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.999 |
| LAX1 | AASS | ENSP00000406970 | ENSP00000377040 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively | 0.681 |
| LAX1 | ALDH18A1 | ENSP00000406970 | ENSP00000360268 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | aldehyde dehydrogenase 18 family, member A1 | 0.748 |
| LAX1 | COL12A1 | ENSP00000406970 | ENSP00000325146 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) | 0.652 |
| LAX1 | COL19A1 | ENSP00000406970 | ENSP00000316030 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | collagen, type XIX, alpha 1 | 0.669 |
| LAX1 | COMP | ENSP00000406970 | ENSP00000222271 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] | 0.748 |
| LAX1 | GRAP2 | ENSP00000406970 | ENSP00000339186 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.701 |
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