node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPX1 | GSS | ENSP00000407375 | ENSP00000216951 | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | glutathione synthetase | 0.969 |
GPX1 | GSTA4 | ENSP00000407375 | ENSP00000359998 | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | glutathione S-transferase alpha 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE) | 0.942 |
GPX1 | GSTM1 | ENSP00000407375 | ENSP00000311469 | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.948 |
GPX1 | GSTO1 | ENSP00000407375 | ENSP00000358727 | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | glutathione S-transferase omega 1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid | 0.947 |
GPX1 | GSTP1 | ENSP00000407375 | ENSP00000381607 | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | 0.950 |
GPX1 | GSTT1 | ENSP00000407375 | ENSP00000248935 | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | 0.965 |
GPX1 | GSTT2B | ENSP00000407375 | ENSP00000290765 | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | glutathione S-transferase theta 2B (gene/pseudogene); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity | 0.948 |
GPX1 | SOD1 | ENSP00000407375 | ENSP00000270142 | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) | 0.971 |
GPX1 | SOD2 | ENSP00000407375 | ENSP00000356022 | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | superoxide dismutase 2, mitochondrial; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) | 0.969 |
GPX1 | TP53 | ENSP00000407375 | ENSP00000269305 | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.947 |
GSS | GPX1 | ENSP00000216951 | ENSP00000407375 | glutathione synthetase | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | 0.969 |
GSS | GSTA4 | ENSP00000216951 | ENSP00000359998 | glutathione synthetase | glutathione S-transferase alpha 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE) | 0.931 |
GSS | GSTM1 | ENSP00000216951 | ENSP00000311469 | glutathione synthetase | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.938 |
GSS | GSTO1 | ENSP00000216951 | ENSP00000358727 | glutathione synthetase | glutathione S-transferase omega 1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid | 0.931 |
GSS | GSTP1 | ENSP00000216951 | ENSP00000381607 | glutathione synthetase | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | 0.948 |
GSS | GSTT1 | ENSP00000216951 | ENSP00000248935 | glutathione synthetase | glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide | 0.940 |
GSS | GSTT2B | ENSP00000216951 | ENSP00000290765 | glutathione synthetase | glutathione S-transferase theta 2B (gene/pseudogene); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity | 0.930 |
GSTA4 | GPX1 | ENSP00000359998 | ENSP00000407375 | glutathione S-transferase alpha 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE) | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | 0.942 |
GSTA4 | GSS | ENSP00000359998 | ENSP00000216951 | glutathione S-transferase alpha 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE) | glutathione synthetase | 0.931 |
GSTA4 | GSTM1 | ENSP00000359998 | ENSP00000311469 | glutathione S-transferase alpha 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE) | glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.964 |