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SOD1 SOD1 SOD2 SOD2 GSTP1 GSTP1 TP53 TP53 GPX1 GPX1 GSTO1 GSTO1 GSTM1 GSTM1 GSS GSS GSTT1 GSTT1 GSTT2B GSTT2B GSTA4 GSTA4
"GPX1" - glutathione peroxidase 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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from curated databases
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experimentally determined
Predicted Interactions
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gene co-occurrence
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protein homology
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Score
GPX1glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown (203 aa)    
Predicted Functional Partners:
SOD1
superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (154 aa)
      score_image   score_image score_image   0.971
SOD2
superoxide dismutase 2, mitochondrial; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (222 aa)
          score_image score_image   0.969
GSS
glutathione synthetase (474 aa)
          score_image score_image   0.969
GSTT1
glutathione S-transferase theta 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide (240 aa)
      score_image   score_image score_image   0.965
GSTP1
glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (210 aa)
          score_image score_image   0.950
GSTT2B
glutathione S-transferase theta 2B (gene/pseudogene); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity (244 aa)
      score_image   score_image score_image   0.948
GSTM1
glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (218 aa)
          score_image score_image   0.948
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) (393 aa)
          score_image score_image   0.947
GSTO1
glutathione S-transferase omega 1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid (241 aa)
          score_image score_image   0.947
GSTA4
glutathione S-transferase alpha 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE) (222 aa)
          score_image score_image   0.942
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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