node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTA1 | GAS7 | ENSP00000355645 | ENSP00000407552 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | 0.862 |
ACTA1 | WIPF1 | ENSP00000355645 | ENSP00000352802 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | WAS/WASL interacting protein family, member 1; Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus | 0.712 |
ACTA1 | WIPF2 | ENSP00000355645 | ENSP00000320924 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | WAS/WASL interacting protein family, member 2; Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system | 0.720 |
GAS7 | ACTA1 | ENSP00000407552 | ENSP00000355645 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.862 |
GAS7 | KY | ENSP00000407552 | ENSP00000397598 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | kyphoscoliosis peptidase; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity) | 0.822 |
GAS7 | LATS1 | ENSP00000407552 | ENSP00000253339 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | LATS, large tumor suppressor, homolog 1 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation in [...] | 0.923 |
GAS7 | LATS2 | ENSP00000407552 | ENSP00000372035 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | LATS, large tumor suppressor, homolog 2 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation in [...] | 0.923 |
GAS7 | MYOC | ENSP00000407552 | ENSP00000037502 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | myocilin, trabecular meshwork inducible glucocorticoid response; May participate in the obstruction of fluid outflow in the trabecular meshwork | 0.823 |
GAS7 | PTPN23 | ENSP00000407552 | ENSP00000265562 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.875 |
GAS7 | STK38 | ENSP00000407552 | ENSP00000229812 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | serine/threonine kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 | 0.923 |
GAS7 | STK38L | ENSP00000407552 | ENSP00000373684 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | serine/threonine kinase 38 like; Involved in the regulation of structural processes in differentiating and mature neuronal cells (By similarity) | 0.923 |
GAS7 | WIPF1 | ENSP00000407552 | ENSP00000352802 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | WAS/WASL interacting protein family, member 1; Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus | 0.893 |
GAS7 | WIPF2 | ENSP00000407552 | ENSP00000320924 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | WAS/WASL interacting protein family, member 2; Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system | 0.890 |
KY | GAS7 | ENSP00000397598 | ENSP00000407552 | kyphoscoliosis peptidase; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity) | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | 0.822 |
LATS1 | GAS7 | ENSP00000253339 | ENSP00000407552 | LATS, large tumor suppressor, homolog 1 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation in [...] | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | 0.923 |
LATS1 | LATS2 | ENSP00000253339 | ENSP00000372035 | LATS, large tumor suppressor, homolog 1 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation in [...] | LATS, large tumor suppressor, homolog 2 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation in [...] | 0.973 |
LATS2 | GAS7 | ENSP00000372035 | ENSP00000407552 | LATS, large tumor suppressor, homolog 2 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation in [...] | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | 0.923 |
LATS2 | LATS1 | ENSP00000372035 | ENSP00000253339 | LATS, large tumor suppressor, homolog 2 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation in [...] | LATS, large tumor suppressor, homolog 1 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation in [...] | 0.973 |
MYOC | GAS7 | ENSP00000037502 | ENSP00000407552 | myocilin, trabecular meshwork inducible glucocorticoid response; May participate in the obstruction of fluid outflow in the trabecular meshwork | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | 0.823 |
PTPN23 | GAS7 | ENSP00000265562 | ENSP00000407552 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | 0.875 |