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ACTA1 ACTA1 WIPF2 WIPF2 WIPF1 WIPF1 KY KY STK38L STK38L PTPN23 PTPN23 GAS7 GAS7 STK38 STK38 MYOC MYOC LATS1 LATS1 LATS2 LATS2
"GAS7" - growth arrest-specific 7 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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GAS7growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons (476 aa)    
Predicted Functional Partners:
STK38L
serine/threonine kinase 38 like; Involved in the regulation of structural processes in differentiating and mature neuronal cells (By similarity) (464 aa)
        score_image   score_image   0.923
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation in [...] (1088 aa)
        score_image   score_image   0.923
LATS1
LATS, large tumor suppressor, homolog 1 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation in [...] (1130 aa)
        score_image   score_image   0.923
STK38
serine/threonine kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (465 aa)
        score_image   score_image   0.923
WIPF1
WAS/WASL interacting protein family, member 1; Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus (503 aa)
        score_image   score_image   0.893
WIPF2
WAS/WASL interacting protein family, member 2; Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system (440 aa)
        score_image   score_image   0.890
PTPN23
protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (1636 aa)
        score_image   score_image   0.875
ACTA1
actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa)
        score_image   score_image   0.862
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response; May participate in the obstruction of fluid outflow in the trabecular meshwork (504 aa)
            score_image   0.823
KY
kyphoscoliosis peptidase; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity) (661 aa)
        score_image   score_image   0.822
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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