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ZNF687 ZNF687 UBE2O UBE2O YPEL5 YPEL5 WDR26 WDR26 RANBP10 RANBP10 RANBP9 RANBP9 MAEA MAEA GID8 GID8 ARMC8 ARMC8 RMND5A RMND5A SPRYD3 SPRYD3
"WDR26" - WD repeat domain 26 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
WDR26WD repeat domain 26; May be involved in MAPK pathways (661 aa)    
Predicted Functional Partners:
UBE2O
ubiquitin-conjugating enzyme E2O (1292 aa)
        score_image       0.995
RANBP10
RAN binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] (620 aa)
      score_image score_image   score_image   0.983
ZNF687
zinc finger protein 687; May be involved in transcriptional regulation (1237 aa)
      score_image score_image       0.980
GID8
GID complex subunit 8 homolog (S. cerevisiae) (228 aa)
        score_image   score_image   0.980
RANBP9
RAN binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] (729 aa)
      score_image score_image   score_image   0.977
MAEA
macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (396 aa)
      score_image score_image   score_image   0.950
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae) (391 aa)
      score_image score_image   score_image   0.889
SPRYD3
SPRY domain containing 3 (442 aa)
      score_image score_image   score_image   0.868
ARMC8
armadillo repeat containing 8 (659 aa)
        score_image   score_image   0.859
YPEL5
yippee-like 5 (Drosophila) (121 aa)
        score_image   score_image   0.847
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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