| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADARB1 | CCDC124 | ENSP00000353920 | ENSP00000408730 | adenosine deaminase, RNA-specific, B1 | coiled-coil domain containing 124 | 0.481 |
| APEX1 | CCDC124 | ENSP00000216714 | ENSP00000408730 | APEX nuclease (multifunctional DNA repair enzyme) 1; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5’ [...] | coiled-coil domain containing 124 | 0.400 |
| APEX1 | UBC | ENSP00000216714 | ENSP00000344818 | APEX nuclease (multifunctional DNA repair enzyme) 1; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5’ [...] | ubiquitin C | 0.891 |
| CCDC124 | ADARB1 | ENSP00000408730 | ENSP00000353920 | coiled-coil domain containing 124 | adenosine deaminase, RNA-specific, B1 | 0.481 |
| CCDC124 | APEX1 | ENSP00000408730 | ENSP00000216714 | coiled-coil domain containing 124 | APEX nuclease (multifunctional DNA repair enzyme) 1; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5’ [...] | 0.400 |
| CCDC124 | EIF2AK1 | ENSP00000408730 | ENSP00000199389 | coiled-coil domain containing 124 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.447 |
| CCDC124 | EIF2AK2 | ENSP00000408730 | ENSP00000233057 | coiled-coil domain containing 124 | eukaryotic translation initiation factor 2-alpha kinase 2; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 ( [...] | 0.461 |
| CCDC124 | EIF3J | ENSP00000408730 | ENSP00000261868 | coiled-coil domain containing 124 | eukaryotic translation initiation factor 3, subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.781 |
| CCDC124 | PRKRA | ENSP00000408730 | ENSP00000318176 | coiled-coil domain containing 124 | protein kinase, interferon-inducible double stranded RNA dependent activator; Activates EIF2AK2/PKR in the absence of double stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at ’Lys-386’ at ’Ser-392’ respectively and enhances its activity in [...] | 0.481 |
| CCDC124 | UBC | ENSP00000408730 | ENSP00000344818 | coiled-coil domain containing 124 | ubiquitin C | 0.483 |
| CCDC124 | ZNF346 | ENSP00000408730 | ENSP00000350869 | coiled-coil domain containing 124 | zinc finger protein 346; Binds to dsRNA and DNA (By similarity) | 0.481 |
| EIF2AK1 | CCDC124 | ENSP00000199389 | ENSP00000408730 | eukaryotic translation initiation factor 2-alpha kinase 1 | coiled-coil domain containing 124 | 0.447 |
| EIF2AK1 | EIF2AK2 | ENSP00000199389 | ENSP00000233057 | eukaryotic translation initiation factor 2-alpha kinase 1 | eukaryotic translation initiation factor 2-alpha kinase 2; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 ( [...] | 0.916 |
| EIF2AK1 | UBC | ENSP00000199389 | ENSP00000344818 | eukaryotic translation initiation factor 2-alpha kinase 1 | ubiquitin C | 0.631 |
| EIF2AK1 | ZNF346 | ENSP00000199389 | ENSP00000350869 | eukaryotic translation initiation factor 2-alpha kinase 1 | zinc finger protein 346; Binds to dsRNA and DNA (By similarity) | 0.447 |
| EIF2AK2 | CCDC124 | ENSP00000233057 | ENSP00000408730 | eukaryotic translation initiation factor 2-alpha kinase 2; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 ( [...] | coiled-coil domain containing 124 | 0.461 |
| EIF2AK2 | EIF2AK1 | ENSP00000233057 | ENSP00000199389 | eukaryotic translation initiation factor 2-alpha kinase 2; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 ( [...] | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.916 |
| EIF2AK2 | PRKRA | ENSP00000233057 | ENSP00000318176 | eukaryotic translation initiation factor 2-alpha kinase 2; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 ( [...] | protein kinase, interferon-inducible double stranded RNA dependent activator; Activates EIF2AK2/PKR in the absence of double stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at ’Lys-386’ at ’Ser-392’ respectively and enhances its activity in [...] | 0.999 |
| EIF2AK2 | UBC | ENSP00000233057 | ENSP00000344818 | eukaryotic translation initiation factor 2-alpha kinase 2; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 ( [...] | ubiquitin C | 0.800 |
| EIF2AK2 | ZNF346 | ENSP00000233057 | ENSP00000350869 | eukaryotic translation initiation factor 2-alpha kinase 2; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 ( [...] | zinc finger protein 346; Binds to dsRNA and DNA (By similarity) | 0.480 |
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