| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACRV1 | SP8 | ENSP00000432816 | ENSP00000408792 | acrosomal vesicle protein 1 | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.720 |
| CALB2 | GSX2 | ENSP00000307508 | ENSP00000319118 | calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons | GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) | 0.536 |
| CALB2 | SP8 | ENSP00000307508 | ENSP00000408792 | calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.780 |
| DNAH11 | SP8 | ENSP00000330671 | ENSP00000408792 | dynein, axonemal, heavy chain 11; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.745 |
| DNAH11 | WNT3 | ENSP00000330671 | ENSP00000225512 | dynein, axonemal, heavy chain 11; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP | wingless-type MMTV integration site family, member 3; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity) | 0.452 |
| FGF8 | GSX2 | ENSP00000321797 | ENSP00000319118 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) | 0.442 |
| FGF8 | SP8 | ENSP00000321797 | ENSP00000408792 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.783 |
| FGF8 | WNT3 | ENSP00000321797 | ENSP00000225512 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | wingless-type MMTV integration site family, member 3; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity) | 0.831 |
| GSX2 | CALB2 | ENSP00000319118 | ENSP00000307508 | GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) | calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons | 0.536 |
| GSX2 | FGF8 | ENSP00000319118 | ENSP00000321797 | GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.442 |
| GSX2 | SP8 | ENSP00000319118 | ENSP00000408792 | GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.962 |
| PDCD2 | RAPGEF4 | ENSP00000439467 | ENSP00000380271 | programmed cell death 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation | Rap guanine nucleotide exchange factor (GEF) 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity) | 0.643 |
| PDCD2 | SP8 | ENSP00000439467 | ENSP00000408792 | programmed cell death 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.817 |
| RAPGEF4 | PDCD2 | ENSP00000380271 | ENSP00000439467 | Rap guanine nucleotide exchange factor (GEF) 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity) | programmed cell death 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation | 0.643 |
| RAPGEF4 | SP8 | ENSP00000380271 | ENSP00000408792 | Rap guanine nucleotide exchange factor (GEF) 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity) | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.683 |
| RSPO2 | SP8 | ENSP00000276659 | ENSP00000408792 | R-spondin 2; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (By similarity) | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.826 |
| RUNX1 | SP8 | ENSP00000300305 | ENSP00000408792 | runt-related transcription factor 1 | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.698 |
| SP8 | ACRV1 | ENSP00000408792 | ENSP00000432816 | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | acrosomal vesicle protein 1 | 0.720 |
| SP8 | CALB2 | ENSP00000408792 | ENSP00000307508 | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons | 0.780 |
| SP8 | DNAH11 | ENSP00000408792 | ENSP00000330671 | Sp8 transcription factor; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | dynein, axonemal, heavy chain 11; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP | 0.745 |
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