CYP21A2 protein (Homo sapiens) - STRING network view

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CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2 (495 aa)

Predicted Functional Partners:

EGR1

0.812

AGT

0.798

MC2R

0.763

HSD3B2

0.720

NR5A1

0.708

C4B

0.677

C4A

0.653

POMC

0.639

FDX1

0.633

HSD17B6

0.611

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	CYP21A2	ENSP00000355627	ENSP00000408860	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	cytochrome P450, family 21, subfamily A, polypeptide 2	0.798
AGT	EGR1	ENSP00000355627	ENSP00000239938	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	0.845
AGT	HSD17B6	ENSP00000355627	ENSP00000318631	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...]	0.472
AGT	NR5A1	ENSP00000355627	ENSP00000362690	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	nuclear receptor subfamily 5, group A, member 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5’-YCAAGGYC-3’ and 5’-RRAGGTCA-3’ are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional a [...]	0.791
AGT	POMC	ENSP00000355627	ENSP00000264708	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.947
C4A	CYP21A2	ENSP00000396688	ENSP00000408860	complement component 4A (Rodgers blood group)	cytochrome P450, family 21, subfamily A, polypeptide 2	0.653
C4B	CYP21A2	ENSP00000415941	ENSP00000408860	complement component 4B (Chido blood group)	cytochrome P450, family 21, subfamily A, polypeptide 2	0.677
CYP21A2	AGT	ENSP00000408860	ENSP00000355627	cytochrome P450, family 21, subfamily A, polypeptide 2	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	0.798
CYP21A2	C4A	ENSP00000408860	ENSP00000396688	cytochrome P450, family 21, subfamily A, polypeptide 2	complement component 4A (Rodgers blood group)	0.653
CYP21A2	C4B	ENSP00000408860	ENSP00000415941	cytochrome P450, family 21, subfamily A, polypeptide 2	complement component 4B (Chido blood group)	0.677
CYP21A2	EGR1	ENSP00000408860	ENSP00000239938	cytochrome P450, family 21, subfamily A, polypeptide 2	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	0.812
CYP21A2	FDX1	ENSP00000408860	ENSP00000260270	cytochrome P450, family 21, subfamily A, polypeptide 2	ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage	0.633
CYP21A2	HSD17B6	ENSP00000408860	ENSP00000318631	cytochrome P450, family 21, subfamily A, polypeptide 2	hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...]	0.611
CYP21A2	HSD3B2	ENSP00000408860	ENSP00000358424	cytochrome P450, family 21, subfamily A, polypeptide 2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids	0.720
CYP21A2	MC2R	ENSP00000408860	ENSP00000333821	cytochrome P450, family 21, subfamily A, polypeptide 2	melanocortin 2 receptor (adrenocorticotropic hormone); Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase	0.763
CYP21A2	NR5A1	ENSP00000408860	ENSP00000362690	cytochrome P450, family 21, subfamily A, polypeptide 2	nuclear receptor subfamily 5, group A, member 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5’-YCAAGGYC-3’ and 5’-RRAGGTCA-3’ are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional a [...]	0.708
CYP21A2	POMC	ENSP00000408860	ENSP00000264708	cytochrome P450, family 21, subfamily A, polypeptide 2	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.639
EGR1	AGT	ENSP00000239938	ENSP00000355627	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	0.845
EGR1	CYP21A2	ENSP00000239938	ENSP00000408860	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	cytochrome P450, family 21, subfamily A, polypeptide 2	0.812
EGR1	POMC	ENSP00000239938	ENSP00000264708	early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.418

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