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STRINGSTRING
TRAK1 TRAK1 KLC1 KLC1 KIF26A KIF26A ENSG00000256500 ENSG00000256500 KLC4 KLC4 KLC2 KLC2 KIF5A KIF5A KLC3 KLC3 NDEL1 NDEL1 DISC1 DISC1 ZFYVE27 ZFYVE27
"KIF5A" - kinesin family member 5A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIF5Akinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) (1032 aa)    
Predicted Functional Partners:
KLC1
kinesin light chain 1 (618 aa)
        score_image score_image score_image   0.999
KLC2
kinesin light chain 2; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity) (622 aa)
        score_image score_image score_image   0.999
KLC4
kinesin light chain 4; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity) (637 aa)
        score_image   score_image   0.998
KIF26A
kinesin family member 26A; Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity) (1882 aa)
          score_image score_image score_image 0.922
ENSG00000256500
Kinesin light chain 1 (732 aa)
        score_image   score_image   0.913
TRAK1
trafficking protein, kinesin binding 1; Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (953 aa)
        score_image   score_image   0.902
NDEL1
nudE nuclear distribution E homolog (A. nidulans)-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integri [...] (345 aa)
            score_image   0.891
KLC3
kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (504 aa)
        score_image   score_image   0.846
ZFYVE27
zinc finger, FYVE domain containing 27 (416 aa)
            score_image   0.840
DISC1
disrupted in schizophrenia 1 (755 aa)
            score_image   0.836
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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