| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACSM3 | CBFA2T2 | ENSP00000289416 | ENSP00000262653 | acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity) | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.703 |
| ACSM3 | KAT6B | ENSP00000289416 | ENSP00000287239 | acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity) | K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | 0.739 |
| ACSM3 | TBRG1 | ENSP00000289416 | ENSP00000409016 | acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity) | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | 0.581 |
| CBFA2T2 | ACSM3 | ENSP00000262653 | ENSP00000289416 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity) | 0.703 |
| CBFA2T2 | KAT6B | ENSP00000262653 | ENSP00000287239 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | 0.726 |
| CBFA2T2 | TBRG1 | ENSP00000262653 | ENSP00000409016 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | 0.580 |
| CDKN2A | MDM2 | ENSP00000394932 | ENSP00000417281 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | 0.999 |
| CDKN2A | RABL6 | ENSP00000394932 | ENSP00000360727 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | RAB, member RAS oncogene family-like 6 | 0.410 |
| CDKN2A | TBRG1 | ENSP00000394932 | ENSP00000409016 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | 0.749 |
| CDKN2A | UBC | ENSP00000394932 | ENSP00000344818 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | ubiquitin C | 0.998 |
| INO80E | TBRG1 | ENSP00000457016 | ENSP00000409016 | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | 0.549 |
| KAT6B | ACSM3 | ENSP00000287239 | ENSP00000289416 | K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity) | 0.739 |
| KAT6B | CBFA2T2 | ENSP00000287239 | ENSP00000262653 | K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.726 |
| KAT6B | TBRG1 | ENSP00000287239 | ENSP00000409016 | K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | 0.568 |
| KAT6B | UBC | ENSP00000287239 | ENSP00000344818 | K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | ubiquitin C | 0.655 |
| MDM2 | CDKN2A | ENSP00000417281 | ENSP00000394932 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | 0.999 |
| MDM2 | TBRG1 | ENSP00000417281 | ENSP00000409016 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | 0.577 |
| MDM2 | UBC | ENSP00000417281 | ENSP00000344818 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | ubiquitin C | 0.999 |
| RABL6 | CDKN2A | ENSP00000360727 | ENSP00000394932 | RAB, member RAS oncogene family-like 6 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | 0.410 |
| RABL6 | TBRG1 | ENSP00000360727 | ENSP00000409016 | RAB, member RAS oncogene family-like 6 | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | 0.753 |
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