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NELL1 NELL1 NELL2 NELL2 SLC9A3R2 SLC9A3R2 XKR8 XKR8 ANO6 ANO6 CFTR CFTR BEST2 BEST2 UBC UBC BEST3 BEST3 TTYH3 TTYH3 CTSC CTSC
"ANO6" - anoctamin 6 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ANO6anoctamin 6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (931 aa)    
Predicted Functional Partners:
NELL2
NEL-like 2 (chicken) (866 aa)
            score_image   0.860
UBC
ubiquitin C (685 aa)
        score_image       0.849
NELL1
NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization (810 aa)
            score_image   0.813
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus (337 aa)
            score_image   0.804
BEST2
bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (509 aa)
          score_image score_image   0.693
CTSC
cathepsin C (463 aa)
            score_image   0.656
XKR8
XK, Kell blood group complex subunit-related family, member 8 (395 aa)
            score_image   0.651
BEST3
bestrophin 3; Forms calcium-sensitive (By similarity) chloride channels. Permeable to bicarbonate (By similarity) (668 aa)
          score_image score_image   0.643
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
          score_image score_image   0.619
TTYH3
tweety homolog 3 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (523 aa)
          score_image score_image   0.603
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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