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ATN1 ATN1 NAA10 NAA10 NXPH2 NXPH2 KIF19 KIF19 EFCAB4B EFCAB4B ORAI1 ORAI1 TRIM29 TRIM29 ORAI3 ORAI3 STIM1 STIM1 ORAI2 ORAI2 ZNF473 ZNF473
"EFCAB4B" - EF-hand calcium binding domain 4B in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
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textmining
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protein homology
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Score
EFCAB4BEF-hand calcium binding domain 4B; Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, ther [...] (731 aa)    
Predicted Functional Partners:
ORAI1
ORAI calcium release-activated calcium modulator 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (303 aa)
        score_image   score_image   0.802
STIM1
stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1 (685 aa)
        score_image   score_image   0.761
ORAI2
ORAI calcium release-activated calcium modulator 2; Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1 (254 aa)
        score_image   score_image   0.701
ORAI3
ORAI calcium release-activated calcium modulator 3; Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import (By similarity) (295 aa)
        score_image   score_image   0.701
TRIM29
tripartite motif containing 29; It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line (588 aa)
        score_image   score_image   0.513
NXPH2
neurexophilin 2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (Potential) (264 aa)
            score_image   0.472
ATN1
atrophin 1; Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats (1190 aa)
            score_image   0.459
ZNF473
zinc finger protein 473; Involved in histone 3’-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3’-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases (871 aa)
            score_image   0.416
NAA10
N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (235 aa)
            score_image   0.412
KIF19
kinesin family member 19; Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips (By similarity) (998 aa)
            score_image   0.408
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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