node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CXCL10 | ZNF740 | ENSP00000305651 | ENSP00000409463 | chemokine (C-X-C motif) ligand 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 | zinc finger protein 740; May be involved in transcriptional regulation | 0.561 |
FBXL19 | ZNF740 | ENSP00000369666 | ENSP00000409463 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 740; May be involved in transcriptional regulation | 0.501 |
KDM2A | UBC | ENSP00000432786 | ENSP00000344818 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | ubiquitin C | 0.740 |
KDM2A | ZNF740 | ENSP00000432786 | ENSP00000409463 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 740; May be involved in transcriptional regulation | 0.501 |
PDE6B | TMSB10 | ENSP00000420295 | ENSP00000233143 | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | thymosin beta 10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity) | 0.561 |
PDE6B | ZNF740 | ENSP00000420295 | ENSP00000409463 | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | zinc finger protein 740; May be involved in transcriptional regulation | 0.785 |
REEP5 | SLC25A46 | ENSP00000368959 | ENSP00000348211 | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors | solute carrier family 25, member 46 | 0.820 |
REEP5 | TBRG1 | ENSP00000368959 | ENSP00000409016 | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | 0.609 |
REEP5 | UBC | ENSP00000368959 | ENSP00000344818 | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors | ubiquitin C | 0.850 |
REEP5 | ZNF740 | ENSP00000368959 | ENSP00000409463 | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors | zinc finger protein 740; May be involved in transcriptional regulation | 0.534 |
SLC25A46 | REEP5 | ENSP00000348211 | ENSP00000368959 | solute carrier family 25, member 46 | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors | 0.820 |
SLC25A46 | TBRG1 | ENSP00000348211 | ENSP00000409016 | solute carrier family 25, member 46 | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | 0.513 |
SLC25A46 | UBC | ENSP00000348211 | ENSP00000344818 | solute carrier family 25, member 46 | ubiquitin C | 0.620 |
SLC25A46 | ZNF740 | ENSP00000348211 | ENSP00000409463 | solute carrier family 25, member 46 | zinc finger protein 740; May be involved in transcriptional regulation | 0.630 |
TBRG1 | REEP5 | ENSP00000409016 | ENSP00000368959 | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors | 0.609 |
TBRG1 | SLC25A46 | ENSP00000409016 | ENSP00000348211 | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | solute carrier family 25, member 46 | 0.513 |
TBRG1 | TMSB10 | ENSP00000409016 | ENSP00000233143 | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | thymosin beta 10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity) | 0.480 |
TBRG1 | UBC | ENSP00000409016 | ENSP00000344818 | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | ubiquitin C | 0.576 |
TBRG1 | ZNF740 | ENSP00000409016 | ENSP00000409463 | transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability | zinc finger protein 740; May be involved in transcriptional regulation | 0.623 |
TMSB10 | PDE6B | ENSP00000233143 | ENSP00000420295 | thymosin beta 10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity) | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | 0.561 |