VPS52 protein (Homo sapiens) - STRING network view

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VPS52

vacuolar protein sorting 52 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (723 aa)

Predicted Functional Partners:

VPS54

0.999

VPS53

0.991

VPS51

0.885

STX6

0.838

RPS18

0.837

RAB6A

0.779

VPS16

0.772

ENSG00000260371

0.760

SOAT2

0.757

VAMP4

0.739

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSG00000260371	RAB6A	ENSP00000454500	ENSP00000311449	Uncharacterized protein	RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity	0.667
ENSG00000260371	STX6	ENSP00000454500	ENSP00000258301	Uncharacterized protein	syntaxin 6; Involved in intracellular vesicle trafficking	0.408
ENSG00000260371	VPS16	ENSP00000454500	ENSP00000369810	Uncharacterized protein	vacuolar protein sorting 16 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes	0.623
ENSG00000260371	VPS52	ENSP00000454500	ENSP00000409952	Uncharacterized protein	vacuolar protein sorting 52 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.760
ENSG00000260371	VPS53	ENSP00000454500	ENSP00000401435	Uncharacterized protein	vacuolar protein sorting 53 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.583
ENSG00000260371	VPS54	ENSP00000454500	ENSP00000272322	Uncharacterized protein	vacuolar protein sorting 54 homolog (S. cerevisiae); May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.581
RAB6A	ENSG00000260371	ENSP00000311449	ENSP00000454500	RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity	Uncharacterized protein	0.667
RAB6A	STX6	ENSP00000311449	ENSP00000258301	RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity	syntaxin 6; Involved in intracellular vesicle trafficking	0.747
RAB6A	VAMP4	ENSP00000311449	ENSP00000236192	RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity	vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule	0.727
RAB6A	VPS52	ENSP00000311449	ENSP00000409952	RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity	vacuolar protein sorting 52 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.779
RAB6A	VPS53	ENSP00000311449	ENSP00000401435	RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity	vacuolar protein sorting 53 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.894
RAB6A	VPS54	ENSP00000311449	ENSP00000272322	RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity	vacuolar protein sorting 54 homolog (S. cerevisiae); May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.816
RPS18	VPS52	ENSP00000393241	ENSP00000409952	ribosomal protein S18	vacuolar protein sorting 52 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.837
SOAT2	VPS52	ENSP00000301466	ENSP00000409952	sterol O-acyltransferase 2; Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa	vacuolar protein sorting 52 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.757
STX6	ENSG00000260371	ENSP00000258301	ENSP00000454500	syntaxin 6; Involved in intracellular vesicle trafficking	Uncharacterized protein	0.408
STX6	RAB6A	ENSP00000258301	ENSP00000311449	syntaxin 6; Involved in intracellular vesicle trafficking	RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity	0.747
STX6	VAMP4	ENSP00000258301	ENSP00000236192	syntaxin 6; Involved in intracellular vesicle trafficking	vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule	0.999
STX6	VPS51	ENSP00000258301	ENSP00000279281	syntaxin 6; Involved in intracellular vesicle trafficking	vacuolar protein sorting 51 homolog (S. cerevisiae); Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN	0.808
STX6	VPS52	ENSP00000258301	ENSP00000409952	syntaxin 6; Involved in intracellular vesicle trafficking	vacuolar protein sorting 52 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.838
STX6	VPS53	ENSP00000258301	ENSP00000401435	syntaxin 6; Involved in intracellular vesicle trafficking	vacuolar protein sorting 53 homolog (S. cerevisiae); May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.818

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