Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | FBXO46 | F-box protein 46; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) (603 aa) | ||||||||||||
Predicted Functional Partners:
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 | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
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0.960 | |||||||||
 | CUL1 | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] (776 aa) |
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0.817 | |||||||||
 | FADS6 | fatty acid desaturase domain family, member 6 (350 aa) |
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0.537 | ||||||||||
 | PRRT4 | proline-rich transmembrane protein 4 (899 aa) |
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0.536 | ||||||||||
 | LRRC10 | leucine rich repeat containing 10; May play important roles in cardiac development and/or cardiac function (By similarity) (277 aa) |
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0.510 | ||||||||||
 | CCDC47 | coiled-coil domain containing 47 (483 aa) |
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0.506 | ||||||||||
 | AGBL5 | ATP/GTP binding protein-like 5 (886 aa) |
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0.504 | ||||||||||
 | DUPD1 | dual specificity phosphatase and pro isomerase domain containing 1 (220 aa) |
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0.459 | ||||||||||
 | KCTD17 | potassium channel tetramerisation domain containing 17 (297 aa) |
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0.414 | ||||||||||
 | TBKBP1 | TBK1 binding protein 1; Adapter protein which constitutively binds TBK1 and IKBKE and may play a role in antiviral innate immunity (By similarity) (615 aa) |
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0.407 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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