| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CPO | TBC1D26 | ENSP00000272852 | ENSP00000410111 | carboxypeptidase O; Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues (By similarity) | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.569 |
| ENSG00000267261 | TBC1D26 | ENSP00000468367 | ENSP00000410111 | Ras-related protein Rab-5C | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.620 |
| RAB17 | TBC1D26 | ENSP00000264601 | ENSP00000410111 | RAB17, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly obse [...] | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.607 |
| RAB20 | TBC1D26 | ENSP00000267328 | ENSP00000410111 | RAB20, member RAS oncogene family; Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.637 |
| RAB22A | RAB5A | ENSP00000244040 | ENSP00000273047 | RAB22A, member RAS oncogene family; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.599 |
| RAB22A | TBC1D26 | ENSP00000244040 | ENSP00000410111 | RAB22A, member RAS oncogene family; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.607 |
| RAB24 | TBC1D26 | ENSP00000304376 | ENSP00000410111 | RAB24, member RAS oncogene family; May be involved in autophagy-related processes (By similarity) | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.607 |
| RAB31 | TBC1D26 | ENSP00000304565 | ENSP00000410111 | RAB31, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membr [...] | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.607 |
| RAB5A | RAB22A | ENSP00000273047 | ENSP00000244040 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | RAB22A, member RAS oncogene family; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form | 0.599 |
| RAB5A | TBC1D26 | ENSP00000273047 | ENSP00000410111 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.607 |
| RAB5B | TBC1D26 | ENSP00000353444 | ENSP00000410111 | RAB5B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.607 |
| RAB5C | TBC1D26 | ENSP00000345689 | ENSP00000410111 | RAB5C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.607 |
| TBC1D26 | CPO | ENSP00000410111 | ENSP00000272852 | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | carboxypeptidase O; Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues (By similarity) | 0.569 |
| TBC1D26 | ENSG00000267261 | ENSP00000410111 | ENSP00000468367 | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | Ras-related protein Rab-5C | 0.620 |
| TBC1D26 | RAB17 | ENSP00000410111 | ENSP00000264601 | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | RAB17, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly obse [...] | 0.607 |
| TBC1D26 | RAB20 | ENSP00000410111 | ENSP00000267328 | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | RAB20, member RAS oncogene family; Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes | 0.637 |
| TBC1D26 | RAB22A | ENSP00000410111 | ENSP00000244040 | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | RAB22A, member RAS oncogene family; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form | 0.607 |
| TBC1D26 | RAB24 | ENSP00000410111 | ENSP00000304376 | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | RAB24, member RAS oncogene family; May be involved in autophagy-related processes (By similarity) | 0.607 |
| TBC1D26 | RAB31 | ENSP00000410111 | ENSP00000304565 | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | RAB31, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membr [...] | 0.607 |
| TBC1D26 | RAB5A | ENSP00000410111 | ENSP00000273047 | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.607 |
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