node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABTB2 | ALKBH6 | ENSP00000410157 | ENSP00000368152 | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | alkB, alkylation repair homolog 6 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity) | 0.571 |
ABTB2 | CUL3 | ENSP00000410157 | ENSP00000264414 | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | 0.822 |
ABTB2 | DNTT | ENSP00000410157 | ENSP00000360216 | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | deoxynucleotidyltransferase, terminal; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5’-triphosphate to the 3’-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells | 0.567 |
ABTB2 | EEF1A1 | ENSP00000410157 | ENSP00000330054 | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | 0.576 |
ABTB2 | FAM86C1 | ENSP00000410157 | ENSP00000352182 | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | family with sequence similarity 86, member C1 | 0.499 |
ABTB2 | KRTAP5-10 | ENSP00000410157 | ENSP00000381542 | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | keratin associated protein 5-10; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.537 |
ABTB2 | KRTAP5-7 | ENSP00000410157 | ENSP00000417330 | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | keratin associated protein 5-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.505 |
ABTB2 | RBX1 | ENSP00000410157 | ENSP00000216225 | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | ring-box 1, E3 ubiquitin protein ligase; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in pr [...] | 0.567 |
ABTB2 | UBC | ENSP00000410157 | ENSP00000344818 | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | ubiquitin C | 0.682 |
ABTB2 | ZBTB5 | ENSP00000410157 | ENSP00000307604 | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | zinc finger and BTB domain containing 5; May be involved in transcriptional regulation | 0.578 |
ALKBH6 | ABTB2 | ENSP00000368152 | ENSP00000410157 | alkB, alkylation repair homolog 6 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity) | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | 0.571 |
CUL3 | ABTB2 | ENSP00000264414 | ENSP00000410157 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | 0.822 |
CUL3 | DNTT | ENSP00000264414 | ENSP00000360216 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | deoxynucleotidyltransferase, terminal; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5’-triphosphate to the 3’-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells | 0.580 |
CUL3 | RBX1 | ENSP00000264414 | ENSP00000216225 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | ring-box 1, E3 ubiquitin protein ligase; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in pr [...] | 0.999 |
CUL3 | UBC | ENSP00000264414 | ENSP00000344818 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | ubiquitin C | 0.999 |
DNTT | ABTB2 | ENSP00000360216 | ENSP00000410157 | deoxynucleotidyltransferase, terminal; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5’-triphosphate to the 3’-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | 0.567 |
DNTT | CUL3 | ENSP00000360216 | ENSP00000264414 | deoxynucleotidyltransferase, terminal; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5’-triphosphate to the 3’-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | 0.580 |
DNTT | UBC | ENSP00000360216 | ENSP00000344818 | deoxynucleotidyltransferase, terminal; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5’-triphosphate to the 3’-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells | ubiquitin C | 0.901 |
EEF1A1 | ABTB2 | ENSP00000330054 | ENSP00000410157 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) | 0.576 |
EEF1A1 | UBC | ENSP00000330054 | ENSP00000344818 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | ubiquitin C | 0.999 |