node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIF3E | RUNDC3A | ENSP00000220849 | ENSP00000410862 | eukaryotic translation initiation factor 3, subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.725 |
GRN | RUNDC3A | ENSP00000053867 | ENSP00000410862 | granulin | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.601 |
GRN | SLC25A39 | ENSP00000053867 | ENSP00000366299 | granulin | solute carrier family 25, member 39; Required for normal heme biosynthesis (By similarity) | 0.606 |
GRN | TARDBP | ENSP00000053867 | ENSP00000240185 | granulin | TAR DNA binding protein | 0.870 |
MRPL15 | RUNDC3A | ENSP00000260102 | ENSP00000410862 | mitochondrial ribosomal protein L15 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.554 |
RAP1A | RUNDC3A | ENSP00000348786 | ENSP00000410862 | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.617 |
RAP1A | SGSM3 | ENSP00000348786 | ENSP00000248929 | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells | 0.722 |
RAP2A | RUNDC3A | ENSP00000245304 | ENSP00000410862 | RAP2A, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.800 |
RAP2A | SGSM3 | ENSP00000245304 | ENSP00000248929 | RAP2A, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading | small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells | 0.779 |
RAP2B | RUNDC3A | ENSP00000319096 | ENSP00000410862 | RAP2B, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.727 |
RAP2B | SGSM3 | ENSP00000319096 | ENSP00000248929 | RAP2B, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells | small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells | 0.790 |
RUNDC3A | EIF3E | ENSP00000410862 | ENSP00000220849 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | eukaryotic translation initiation factor 3, subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.725 |
RUNDC3A | GRN | ENSP00000410862 | ENSP00000053867 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | granulin | 0.601 |
RUNDC3A | MRPL15 | ENSP00000410862 | ENSP00000260102 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | mitochondrial ribosomal protein L15 | 0.554 |
RUNDC3A | RAP1A | ENSP00000410862 | ENSP00000348786 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | 0.617 |
RUNDC3A | RAP2A | ENSP00000410862 | ENSP00000245304 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | RAP2A, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading | 0.800 |
RUNDC3A | RAP2B | ENSP00000410862 | ENSP00000319096 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | RAP2B, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells | 0.727 |
RUNDC3A | RUSC1 | ENSP00000410862 | ENSP00000357336 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | RUN and SH3 domain containing 1; Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway | 0.771 |
RUNDC3A | SGSM3 | ENSP00000410862 | ENSP00000248929 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells | 0.643 |
RUNDC3A | SLC25A39 | ENSP00000410862 | ENSP00000366299 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | solute carrier family 25, member 39; Required for normal heme biosynthesis (By similarity) | 0.766 |