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USP16 USP16 USP21 USP21 MARK2 MARK2 UBC UBC YWHAE YWHAE MARK3 MARK3 YWHAH YWHAH CDC25C CDC25C PKP2 PKP2 YWHAZ YWHAZ MITF MITF
"MARK3" - MAP/microtubule affinity-regulating kinase 3 in Homo sapiens
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MARK3MAP/microtubule affinity-regulating kinase 3; Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on ’Ser-216’. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (753 aa)    
Predicted Functional Partners:
MARK2
MAP/microtubule affinity-regulating kinase 2; Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity an [...] (788 aa)
        score_image   score_image score_image 0.999
CDC25C
cell division cycle 25 homolog C (S. pombe); Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity (473 aa)
        score_image   score_image   0.999
USP16
ubiquitin specific peptidase 16 (823 aa)
        score_image       0.980
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (245 aa)
        score_image   score_image   0.979
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (246 aa)
        score_image   score_image   0.966
USP21
ubiquitin specific peptidase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at ’Lys-4’, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (565 aa)
        score_image   score_image   0.959
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.956
PKP2
plakophilin 2; May play a role in junctional plaques (881 aa)
        score_image   score_image   0.929
MITF
microphthalmia-associated transcription factor (520 aa)
        score_image   score_image   0.924
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (255 aa)
        score_image   score_image   0.918
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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