RAB3GAP1 protein (Homo sapiens) - STRING network view

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RAB3GAP1

RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (988 aa)

Predicted Functional Partners:

RAB3GAP2

0.996

DMXL2

0.977

UBXN6

0.832

MADD

0.818

RAB3A

0.754

MAP1LC3A

0.699

DMXL1

0.662

REEP4

0.630

REEP3

0.629

UBC

0.620

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DMXL1	MADD	ENSP00000309690	ENSP00000310933	Dmx-like 1	MAP-kinase activating death domain	0.560
DMXL1	RAB3GAP1	ENSP00000309690	ENSP00000411418	Dmx-like 1	RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters	0.662
DMXL1	RAB3GAP2	ENSP00000309690	ENSP00000351832	Dmx-like 1	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	0.680
DMXL2	MADD	ENSP00000441858	ENSP00000310933	Dmx-like 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles	MAP-kinase activating death domain	0.811
DMXL2	RAB3A	ENSP00000441858	ENSP00000222256	Dmx-like 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles	RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal	0.807
DMXL2	RAB3GAP1	ENSP00000441858	ENSP00000411418	Dmx-like 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles	RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters	0.977
DMXL2	RAB3GAP2	ENSP00000441858	ENSP00000351832	Dmx-like 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	0.863
DMXL2	UBC	ENSP00000441858	ENSP00000344818	Dmx-like 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles	ubiquitin C	0.507
MADD	DMXL1	ENSP00000310933	ENSP00000309690	MAP-kinase activating death domain	Dmx-like 1	0.560
MADD	DMXL2	ENSP00000310933	ENSP00000441858	MAP-kinase activating death domain	Dmx-like 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles	0.811
MADD	RAB3A	ENSP00000310933	ENSP00000222256	MAP-kinase activating death domain	RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal	0.614
MADD	RAB3GAP1	ENSP00000310933	ENSP00000411418	MAP-kinase activating death domain	RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters	0.818
MADD	RAB3GAP2	ENSP00000310933	ENSP00000351832	MAP-kinase activating death domain	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	0.759
MADD	UBC	ENSP00000310933	ENSP00000344818	MAP-kinase activating death domain	ubiquitin C	0.510
MAP1LC3A	RAB3GAP1	ENSP00000363970	ENSP00000411418	microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes)	RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters	0.699
MAP1LC3A	UBC	ENSP00000363970	ENSP00000344818	microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes)	ubiquitin C	0.945
RAB3A	DMXL2	ENSP00000222256	ENSP00000441858	RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal	Dmx-like 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles	0.807
RAB3A	MADD	ENSP00000222256	ENSP00000310933	RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal	MAP-kinase activating death domain	0.614
RAB3A	RAB3GAP1	ENSP00000222256	ENSP00000411418	RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal	RAB3 GTPase activating protein subunit 1 (catalytic); Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters	0.754
RAB3A	RAB3GAP2	ENSP00000222256	ENSP00000351832	RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	0.740

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