| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BUD31 | CDC5L | ENSP00000222969 | ENSP00000360532 | BUD31 homolog (S. cerevisiae) | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.978 |
| BUD31 | CRNKL1 | ENSP00000222969 | ENSP00000366557 | BUD31 homolog (S. cerevisiae) | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | 0.970 |
| BUD31 | DHX8 | ENSP00000222969 | ENSP00000262415 | BUD31 homolog (S. cerevisiae) | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | 0.964 |
| BUD31 | ISY1-RAB43 | ENSP00000222969 | ENSP00000411822 | BUD31 homolog (S. cerevisiae) | ISY1-RAB43 readthrough; May play a role in pre-mRNA splicing (Potential) | 0.894 |
| BUD31 | PLRG1 | ENSP00000222969 | ENSP00000424417 | BUD31 homolog (S. cerevisiae) | pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity) | 0.974 |
| BUD31 | PRPF19 | ENSP00000222969 | ENSP00000227524 | BUD31 homolog (S. cerevisiae) | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.980 |
| BUD31 | SNRPA1 | ENSP00000222969 | ENSP00000254193 | BUD31 homolog (S. cerevisiae) | small nuclear ribonucleoprotein polypeptide A’; This protein is associated with sn-RNP U2. It helps the A’ protein to bind stem loop IV of U2 snRNA | 0.902 |
| BUD31 | SNW1 | ENSP00000222969 | ENSP00000261531 | BUD31 homolog (S. cerevisiae) | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | 0.962 |
| BUD31 | SYF2 | ENSP00000222969 | ENSP00000236273 | BUD31 homolog (S. cerevisiae) | SYF2 homolog, RNA splicing factor (S. cerevisiae); May be involved in pre-mRNA splicing (By similarity) | 0.836 |
| BUD31 | XAB2 | ENSP00000222969 | ENSP00000351137 | BUD31 homolog (S. cerevisiae) | XPA binding protein 2; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing | 0.936 |
| CDC5L | BUD31 | ENSP00000360532 | ENSP00000222969 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | BUD31 homolog (S. cerevisiae) | 0.978 |
| CDC5L | CRNKL1 | ENSP00000360532 | ENSP00000366557 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | 0.993 |
| CDC5L | DHX8 | ENSP00000360532 | ENSP00000262415 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | 0.899 |
| CDC5L | ISY1-RAB43 | ENSP00000360532 | ENSP00000411822 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | ISY1-RAB43 readthrough; May play a role in pre-mRNA splicing (Potential) | 0.919 |
| CDC5L | PLRG1 | ENSP00000360532 | ENSP00000424417 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity) | 0.999 |
| CDC5L | PRPF19 | ENSP00000360532 | ENSP00000227524 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.999 |
| CDC5L | SNRPA1 | ENSP00000360532 | ENSP00000254193 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | small nuclear ribonucleoprotein polypeptide A’; This protein is associated with sn-RNP U2. It helps the A’ protein to bind stem loop IV of U2 snRNA | 0.994 |
| CDC5L | SNW1 | ENSP00000360532 | ENSP00000261531 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | 0.991 |
| CDC5L | SYF2 | ENSP00000360532 | ENSP00000236273 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | SYF2 homolog, RNA splicing factor (S. cerevisiae); May be involved in pre-mRNA splicing (By similarity) | 0.987 |
| CDC5L | XAB2 | ENSP00000360532 | ENSP00000351137 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | XPA binding protein 2; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing | 0.990 |
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