node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DGKZ | PLCB1 | ENSP00000412178 | ENSP00000338185 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase C, beta 1 (phosphoinositide-specific) | 0.955 |
DGKZ | PLCB2 | ENSP00000412178 | ENSP00000260402 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.958 |
DGKZ | PLCB3 | ENSP00000412178 | ENSP00000279230 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.955 |
DGKZ | PLCB4 | ENSP00000412178 | ENSP00000334105 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase C, beta 4 | 0.955 |
DGKZ | PLCD1 | ENSP00000412178 | ENSP00000430344 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase C, delta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development | 0.952 |
DGKZ | PLCD3 | ENSP00000412178 | ENSP00000313731 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase C, delta 3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow | 0.952 |
DGKZ | PLCD4 | ENSP00000412178 | ENSP00000388631 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase C, delta 4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overex [...] | 0.952 |
DGKZ | PLCE1 | ENSP00000412178 | ENSP00000260766 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase C, epsilon 1 | 0.954 |
DGKZ | PLCG1 | ENSP00000412178 | ENSP00000244007 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | 0.955 |
DGKZ | PLD2 | ENSP00000412178 | ENSP00000263088 | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) | 0.922 |
PLCB1 | DGKZ | ENSP00000338185 | ENSP00000412178 | phospholipase C, beta 1 (phosphoinositide-specific) | diacylglycerol kinase, zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity | 0.955 |
PLCB1 | PLCB2 | ENSP00000338185 | ENSP00000260402 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.904 |
PLCB1 | PLCB3 | ENSP00000338185 | ENSP00000279230 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.902 |
PLCB1 | PLCB4 | ENSP00000338185 | ENSP00000334105 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, beta 4 | 0.905 |
PLCB1 | PLCD1 | ENSP00000338185 | ENSP00000430344 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, delta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development | 0.914 |
PLCB1 | PLCD3 | ENSP00000338185 | ENSP00000313731 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, delta 3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow | 0.913 |
PLCB1 | PLCD4 | ENSP00000338185 | ENSP00000388631 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, delta 4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overex [...] | 0.910 |
PLCB1 | PLCE1 | ENSP00000338185 | ENSP00000260766 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, epsilon 1 | 0.911 |
PLCB1 | PLCG1 | ENSP00000338185 | ENSP00000244007 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | 0.926 |
PLCB1 | PLD2 | ENSP00000338185 | ENSP00000263088 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) | 0.485 |