node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENO1 | ENO3 | ENSP00000234590 | ENSP00000324105 | enolase 1, (alpha) | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | 0.766 |
ENO1 | ENO4 | ENSP00000234590 | ENSP00000345555 | enolase 1, (alpha) | enolase family member 4 | 0.473 |
ENO1 | GAPDH | ENSP00000234590 | ENSP00000229239 | enolase 1, (alpha) | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.999 |
ENO1 | GAPDHS | ENSP00000234590 | ENSP00000222286 | enolase 1, (alpha) | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | 0.945 |
ENO1 | PDHB | ENSP00000234590 | ENSP00000307241 | enolase 1, (alpha) | pyruvate dehydrogenase (lipoamide) beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | 0.588 |
ENO1 | PGAM4 | ENSP00000234590 | ENSP00000412189 | enolase 1, (alpha) | phosphoglycerate mutase family member 4 | 0.710 |
ENO1 | PGK1 | ENSP00000234590 | ENSP00000362413 | enolase 1, (alpha) | phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) | 0.992 |
ENO1 | PGK2 | ENSP00000234590 | ENSP00000305995 | enolase 1, (alpha) | phosphoglycerate kinase 2 | 0.986 |
ENO1 | TPI1 | ENSP00000234590 | ENSP00000229270 | enolase 1, (alpha) | triosephosphate isomerase 1 | 0.991 |
ENO2 | ENO4 | ENSP00000229277 | ENSP00000345555 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | enolase family member 4 | 0.490 |
ENO2 | GAPDH | ENSP00000229277 | ENSP00000229239 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.957 |
ENO2 | GAPDHS | ENSP00000229277 | ENSP00000222286 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | 0.943 |
ENO2 | PDHB | ENSP00000229277 | ENSP00000307241 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | pyruvate dehydrogenase (lipoamide) beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | 0.588 |
ENO2 | PGAM4 | ENSP00000229277 | ENSP00000412189 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | phosphoglycerate mutase family member 4 | 0.710 |
ENO2 | PGK1 | ENSP00000229277 | ENSP00000362413 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) | 0.993 |
ENO2 | PGK2 | ENSP00000229277 | ENSP00000305995 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | phosphoglycerate kinase 2 | 0.989 |
ENO2 | TPI1 | ENSP00000229277 | ENSP00000229270 | enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) | triosephosphate isomerase 1 | 0.990 |
ENO3 | ENO1 | ENSP00000324105 | ENSP00000234590 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | enolase 1, (alpha) | 0.766 |
ENO3 | ENO4 | ENSP00000324105 | ENSP00000345555 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | enolase family member 4 | 0.522 |
ENO3 | GAPDH | ENSP00000324105 | ENSP00000229239 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.958 |