| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FOXP3 | GATA3 | ENSP00000365380 | ENSP00000368632 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | 0.995 |
| FOXP3 | IL10 | ENSP00000365380 | ENSP00000412237 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | 0.962 |
| FOXP3 | IL2 | ENSP00000365380 | ENSP00000226730 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.995 |
| FOXP3 | IL4 | ENSP00000365380 | ENSP00000231449 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.954 |
| FOXP3 | IL6 | ENSP00000365380 | ENSP00000258743 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.944 |
| FOXP3 | IL8 | ENSP00000365380 | ENSP00000306512 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 8 | 0.418 |
| FOXP3 | JUN | ENSP00000365380 | ENSP00000360266 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.942 |
| FOXP3 | STAT6 | ENSP00000365380 | ENSP00000300134 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | signal transducer and activator of transcription 6, interleukin-4 induced; Carries out a dual function- signal transduction and activation of transcription. Involved in interleukin-4 signalling | 0.972 |
| GATA3 | FOXP3 | ENSP00000368632 | ENSP00000365380 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | 0.995 |
| GATA3 | IL10 | ENSP00000368632 | ENSP00000412237 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | 0.989 |
| GATA3 | IL2 | ENSP00000368632 | ENSP00000226730 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.509 |
| GATA3 | IL4 | ENSP00000368632 | ENSP00000231449 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.993 |
| GATA3 | IL6 | ENSP00000368632 | ENSP00000258743 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.407 |
| GATA3 | JUN | ENSP00000368632 | ENSP00000360266 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.740 |
| GATA3 | STAT6 | ENSP00000368632 | ENSP00000300134 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | signal transducer and activator of transcription 6, interleukin-4 induced; Carries out a dual function- signal transduction and activation of transcription. Involved in interleukin-4 signalling | 0.963 |
| IL10 | FOXP3 | ENSP00000412237 | ENSP00000365380 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | 0.962 |
| IL10 | GATA3 | ENSP00000412237 | ENSP00000368632 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | 0.989 |
| IL10 | IL10RA | ENSP00000412237 | ENSP00000227752 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | 0.999 |
| IL10 | IL10RB | ENSP00000412237 | ENSP00000290200 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | 0.991 |
| IL10 | IL2 | ENSP00000412237 | ENSP00000226730 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.963 |
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