node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG14 | CDKL2 | ENSP00000247178 | ENSP00000412365 | autophagy related 14; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 0.516 |
ATG14 | FASTKD1 | ENSP00000247178 | ENSP00000400513 | autophagy related 14; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner | FAST kinase domains 1 | 0.575 |
CBL | CDKL2 | ENSP00000264033 | ENSP00000412365 | Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...] | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 0.570 |
CDKL2 | ATG14 | ENSP00000412365 | ENSP00000247178 | cyclin-dependent kinase-like 2 (CDC2-related kinase) | autophagy related 14; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner | 0.516 |
CDKL2 | CBL | ENSP00000412365 | ENSP00000264033 | cyclin-dependent kinase-like 2 (CDC2-related kinase) | Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...] | 0.570 |
CDKL2 | FASTKD1 | ENSP00000412365 | ENSP00000400513 | cyclin-dependent kinase-like 2 (CDC2-related kinase) | FAST kinase domains 1 | 0.608 |
CDKL2 | FRY | ENSP00000412365 | ENSP00000369600 | cyclin-dependent kinase-like 2 (CDC2-related kinase) | furry homolog (Drosophila); Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation | 0.562 |
CDKL2 | KRTAP11-1 | ENSP00000412365 | ENSP00000330720 | cyclin-dependent kinase-like 2 (CDC2-related kinase) | keratin associated protein 11-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.562 |
CDKL2 | NME5 | ENSP00000412365 | ENSP00000265191 | cyclin-dependent kinase-like 2 (CDC2-related kinase) | NME/NM23 family member 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity) | 0.443 |
CDKL2 | SRY | ENSP00000412365 | ENSP00000372547 | cyclin-dependent kinase-like 2 (CDC2-related kinase) | sex determining region Y; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial interc [...] | 0.483 |
FASTKD1 | ATG14 | ENSP00000400513 | ENSP00000247178 | FAST kinase domains 1 | autophagy related 14; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner | 0.575 |
FASTKD1 | CDKL2 | ENSP00000400513 | ENSP00000412365 | FAST kinase domains 1 | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 0.608 |
FRY | CDKL2 | ENSP00000369600 | ENSP00000412365 | furry homolog (Drosophila); Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 0.562 |
KRTAP11-1 | CDKL2 | ENSP00000330720 | ENSP00000412365 | keratin associated protein 11-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 0.562 |
NME5 | CDKL2 | ENSP00000265191 | ENSP00000412365 | NME/NM23 family member 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity) | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 0.443 |
SRY | CDKL2 | ENSP00000372547 | ENSP00000412365 | sex determining region Y; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial interc [...] | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 0.483 |