Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SLC25A48 | solute carrier family 25, member 48 (157 aa) | ||||||||||||
Predicted Functional Partners:
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 | CCDC62 | coiled-coil domain containing 62; Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR (684 aa) |
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0.504 | ||||||||||
 | NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 (243 aa) |
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0.429 | ||||||||||
 | SLC25A42 | solute carrier family 25, member 42; Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3’,5’- diphosphate (318 aa) |
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0.429 | ||||||||||
 | SLC25A19 | solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria (320 aa) |
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0.429 | ||||||||||
 | SLC25A43 | solute carrier family 25, member 43 (341 aa) |
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0.429 | ||||||||||
 | UBASH3B | ubiquitin associated and SH3 domain containing B; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination (649 aa) |
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0.422 | ||||||||||
 | WDR25 | WD repeat domain 25 (544 aa) |
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0.418 | ||||||||||
 | NDUFB10 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (172 aa) |
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0.417 | |||||||||
 | SLCO3A1 | solute carrier organic anion transporter family, member 3A1; Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed-10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed-16971491) (710 aa) |
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0.407 | ||||||||||
 | SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1; Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway (311 aa) |
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0.402 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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