node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERP27 | FKBP7 | ENSP00000266397 | ENSP00000413152 | endoplasmic reticulum protein 27 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | 0.703 |
ERP27 | FOXRED2 | ENSP00000266397 | ENSP00000216187 | endoplasmic reticulum protein 27 | FAD-dependent oxidoreductase domain containing 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation | 0.644 |
ERP27 | GPX7 | ENSP00000266397 | ENSP00000354677 | endoplasmic reticulum protein 27 | glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks | 0.616 |
ERP27 | MANF | ENSP00000266397 | ENSP00000432799 | endoplasmic reticulum protein 27 | mesencephalic astrocyte-derived neurotrophic factor; Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death | 0.610 |
ERP27 | NENF | ENSP00000266397 | ENSP00000355955 | endoplasmic reticulum protein 27 | neudesin neurotrophic factor; Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme (By similarity) | 0.637 |
ERP27 | PCYOX1 | ENSP00000266397 | ENSP00000387654 | endoplasmic reticulum protein 27 | prenylcysteine oxidase 1; Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine | 0.635 |
ERP27 | SUMF2 | ENSP00000266397 | ENSP00000341938 | endoplasmic reticulum protein 27 | sulfatase modifying factor 2 | 0.622 |
FKBP6 | FKBP7 | ENSP00000252037 | ENSP00000413152 | FK506 binding protein 6, 36kDa | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | 0.592 |
FKBP7 | ERP27 | ENSP00000413152 | ENSP00000266397 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | endoplasmic reticulum protein 27 | 0.703 |
FKBP7 | FKBP6 | ENSP00000413152 | ENSP00000252037 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | FK506 binding protein 6, 36kDa | 0.592 |
FKBP7 | FOXRED2 | ENSP00000413152 | ENSP00000216187 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | FAD-dependent oxidoreductase domain containing 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation | 0.638 |
FKBP7 | GPX7 | ENSP00000413152 | ENSP00000354677 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks | 0.602 |
FKBP7 | MANF | ENSP00000413152 | ENSP00000432799 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | mesencephalic astrocyte-derived neurotrophic factor; Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death | 0.616 |
FKBP7 | NENF | ENSP00000413152 | ENSP00000355955 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | neudesin neurotrophic factor; Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme (By similarity) | 0.640 |
FKBP7 | PCYOX1 | ENSP00000413152 | ENSP00000387654 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | prenylcysteine oxidase 1; Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine | 0.642 |
FKBP7 | PEX19 | ENSP00000413152 | ENSP00000357051 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | 0.592 |
FKBP7 | SUMF2 | ENSP00000413152 | ENSP00000341938 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | sulfatase modifying factor 2 | 0.613 |
FKBP7 | UBQLN4 | ENSP00000413152 | ENSP00000357292 | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | ubiquilin 4; Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation | 0.593 |
FOXRED2 | ERP27 | ENSP00000216187 | ENSP00000266397 | FAD-dependent oxidoreductase domain containing 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation | endoplasmic reticulum protein 27 | 0.644 |
FOXRED2 | FKBP7 | ENSP00000216187 | ENSP00000413152 | FAD-dependent oxidoreductase domain containing 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation | FK506 binding protein 7; PPIases accelerate the folding of proteins during protein synthesis | 0.638 |