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ZNF793 ZNF793 NOTCH2 NOTCH2 C19orf55 C19orf55 SUMO1 SUMO1 ZFHX2 ZFHX2 ZEB1 ZEB1 RBMY1E RBMY1E NOTCH1 NOTCH1 XAGE2 XAGE2 NOTCH3 NOTCH3 NOTCH4 NOTCH4
"ZFHX2" - zinc finger homeobox 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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textmining
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co-expression
homology edge
protein homology
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[Homology]
Score
ZFHX2zinc finger homeobox 2; May be involved in transcriptional regulation (2572 aa)    
Predicted Functional Partners:
NOTCH4
notch 4 (2003 aa)
            score_image   0.642
NOTCH1
notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] (2555 aa)
            score_image   0.642
NOTCH3
notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) (2321 aa)
            score_image   0.642
NOTCH2
notch 2 (2471 aa)
            score_image   0.642
SUMO1
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] (101 aa)
        score_image       0.556
ZEB1
zinc finger E-box binding homeobox 1; Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5’-CANNTG [...] (1125 aa)
            score_image   0.511
C19orf55
chromosome 19 open reading frame 55 (479 aa)
            score_image   0.505
RBMY1E
RNA binding motif protein, Y-linked, family 1, member E; RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis (496 aa)
            score_image   0.501
XAGE2
X antigen family, member 2 (111 aa)
            score_image   0.501
ZNF793
zinc finger protein 793; May be involved in transcriptional regulation (406 aa)
            score_image   0.478
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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