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STRINGSTRING
LMOD1 LMOD1 AP2M1 AP2M1 HNRNPU HNRNPU KRT4 KRT4 KRT14 KRT14 KRT3 KRT3 UBC UBC KRT5 KRT5 HP1BP3 HP1BP3 ABCG2 ABCG2 ITGAV ITGAV
"KRT3" - keratin 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT3keratin 3 (628 aa)    
Predicted Functional Partners:
KRT14
keratin 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro (472 aa)
        score_image   score_image score_image 0.999
KRT5
keratin 5 (590 aa)
        score_image   score_image score_image 0.997
UBC
ubiquitin C (685 aa)
        score_image       0.896
LMOD1
leiomodin 1 (smooth muscle) (600 aa)
            score_image   0.662
HP1BP3
heterochromatin protein 1, binding protein 3 (553 aa)
        score_image       0.644
HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA (825 aa)
        score_image       0.644
ITGAV
integrin, alpha V (1048 aa)
        score_image   score_image   0.644
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2 (655 aa)
            score_image   0.584
KRT4
keratin 4 (520 aa)
            score_image   0.566
AP2M1
adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] (435 aa)
        score_image       0.533
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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