node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALM2 | EGFR | ENSP00000272298 | ENSP00000275493 | calmodulin 2 (phosphorylase kinase, delta) | epidermal growth factor receptor | 0.948 |
CALM2 | FGF12 | ENSP00000272298 | ENSP00000413496 | calmodulin 2 (phosphorylase kinase, delta) | fibroblast growth factor 12; Probably involved in nervous system development and function | 0.902 |
CALM2 | SCN5A | ENSP00000272298 | ENSP00000328968 | calmodulin 2 (phosphorylase kinase, delta) | sodium channel, voltage-gated, type V, alpha subunit | 0.985 |
EGFR | CALM2 | ENSP00000275493 | ENSP00000272298 | epidermal growth factor receptor | calmodulin 2 (phosphorylase kinase, delta) | 0.948 |
EGFR | FGF12 | ENSP00000275493 | ENSP00000413496 | epidermal growth factor receptor | fibroblast growth factor 12; Probably involved in nervous system development and function | 0.887 |
EGFR | FLT4 | ENSP00000275493 | ENSP00000261937 | epidermal growth factor receptor | fms-related tyrosine kinase 4; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodi [...] | 0.514 |
EGFR | PDGFRA | ENSP00000275493 | ENSP00000257290 | epidermal growth factor receptor | platelet-derived growth factor receptor, alpha polypeptide; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining th [...] | 0.717 |
EGFR | PDGFRB | ENSP00000275493 | ENSP00000261799 | epidermal growth factor receptor | platelet-derived growth factor receptor, beta polypeptide; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of n [...] | 0.820 |
FGF12 | CALM2 | ENSP00000413496 | ENSP00000272298 | fibroblast growth factor 12; Probably involved in nervous system development and function | calmodulin 2 (phosphorylase kinase, delta) | 0.902 |
FGF12 | EGFR | ENSP00000413496 | ENSP00000275493 | fibroblast growth factor 12; Probably involved in nervous system development and function | epidermal growth factor receptor | 0.887 |
FGF12 | FGFR1 | ENSP00000413496 | ENSP00000393312 | fibroblast growth factor 12; Probably involved in nervous system development and function | fibroblast growth factor receptor 1 | 0.886 |
FGF12 | FGFR2 | ENSP00000413496 | ENSP00000410294 | fibroblast growth factor 12; Probably involved in nervous system development and function | fibroblast growth factor receptor 2 | 0.891 |
FGF12 | FGFR3 | ENSP00000413496 | ENSP00000339824 | fibroblast growth factor 12; Probably involved in nervous system development and function | fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | 0.886 |
FGF12 | FGFR4 | ENSP00000413496 | ENSP00000292408 | fibroblast growth factor 12; Probably involved in nervous system development and function | fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of [...] | 0.898 |
FGF12 | FLT4 | ENSP00000413496 | ENSP00000261937 | fibroblast growth factor 12; Probably involved in nervous system development and function | fms-related tyrosine kinase 4; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodi [...] | 0.846 |
FGF12 | PDGFRA | ENSP00000413496 | ENSP00000257290 | fibroblast growth factor 12; Probably involved in nervous system development and function | platelet-derived growth factor receptor, alpha polypeptide; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining th [...] | 0.845 |
FGF12 | PDGFRB | ENSP00000413496 | ENSP00000261799 | fibroblast growth factor 12; Probably involved in nervous system development and function | platelet-derived growth factor receptor, beta polypeptide; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of n [...] | 0.844 |
FGF12 | SCN5A | ENSP00000413496 | ENSP00000328968 | fibroblast growth factor 12; Probably involved in nervous system development and function | sodium channel, voltage-gated, type V, alpha subunit | 0.965 |
FGFR1 | FGF12 | ENSP00000393312 | ENSP00000413496 | fibroblast growth factor receptor 1 | fibroblast growth factor 12; Probably involved in nervous system development and function | 0.886 |
FGFR2 | FGF12 | ENSP00000410294 | ENSP00000413496 | fibroblast growth factor receptor 2 | fibroblast growth factor 12; Probably involved in nervous system development and function | 0.891 |