NRBP2 protein (Homo sapiens) - STRING network view

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NRBP2

nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity) (501 aa)

Predicted Functional Partners:

PCMTD2

0.653

KLHDC3

0.647

TSC22D1

0.646

TSC22D4

0.646

KLHDC2

0.637

LONP2

0.549

MLF1

0.534

C1orf228

0.507

ENSG00000121388

0.474

KRTAP4-7

0.472

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf228	NRBP2	ENSP00000420716	ENSP00000414055	chromosome 1 open reading frame 228	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	0.507
ENSG00000121388	NRBP2	ENSP00000372449	ENSP00000414055	Putative uncharacterized protein LOC645739	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	0.474
KLHDC2	NRBP2	ENSP00000298307	ENSP00000414055	kelch domain containing 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	0.637
KLHDC2	PCMTD2	ENSP00000298307	ENSP00000307854	kelch domain containing 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.615
KLHDC3	NRBP2	ENSP00000313995	ENSP00000414055	kelch domain containing 3; May be involved in meiotic recombination process	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	0.647
KLHDC3	PCMTD2	ENSP00000313995	ENSP00000307854	kelch domain containing 3; May be involved in meiotic recombination process	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.646
KRTAP4-7	NRBP2	ENSP00000375236	ENSP00000414055	keratin associated protein 4-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	0.472
LONP2	NRBP2	ENSP00000285737	ENSP00000414055	lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	0.549
MLF1	NRBP2	ENSP00000376568	ENSP00000414055	myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	0.534
NRBP2	C1orf228	ENSP00000414055	ENSP00000420716	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	chromosome 1 open reading frame 228	0.507
NRBP2	ENSG00000121388	ENSP00000414055	ENSP00000372449	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	Putative uncharacterized protein LOC645739	0.474
NRBP2	KLHDC2	ENSP00000414055	ENSP00000298307	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	kelch domain containing 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding	0.637
NRBP2	KLHDC3	ENSP00000414055	ENSP00000313995	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	kelch domain containing 3; May be involved in meiotic recombination process	0.647
NRBP2	KRTAP4-7	ENSP00000414055	ENSP00000375236	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	keratin associated protein 4-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins	0.472
NRBP2	LONP2	ENSP00000414055	ENSP00000285737	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1	0.549
NRBP2	MLF1	ENSP00000414055	ENSP00000376568	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus	0.534
NRBP2	PCMTD2	ENSP00000414055	ENSP00000307854	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.653
NRBP2	TSC22D1	ENSP00000414055	ENSP00000397435	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter	0.646
NRBP2	TSC22D4	ENSP00000414055	ENSP00000300181	nuclear receptor binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation (By similarity)	TSC22 domain family, member 4; Transcriptional repressor	0.646
PCMTD2	KLHDC2	ENSP00000307854	ENSP00000298307	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	kelch domain containing 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding	0.615

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