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MSH5 MSH5 HJURP HJURP MIS18BP1 MIS18BP1 CENPP CENPP RBBP7 RBBP7 CENPN CENPN NPM1 NPM1 CENPO CENPO RBBP4 RBBP4 CENPA CENPA RUVBL1 RUVBL1
"HJURP" - Holliday junction recognition protein in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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HJURPHolliday junction recognition protein; Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions (748 aa)    
Predicted Functional Partners:
CENPA
centromere protein A; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) (140 aa)
      score_image score_image score_image score_image   0.999
RBBP7
retinoblastoma binding protein 7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling [...] (469 aa)
        score_image score_image score_image   0.948
RBBP4
retinoblastoma binding protein 4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome [...] (425 aa)
        score_image score_image score_image   0.947
MSH5
mutS homolog 5 (E. coli) (835 aa)
            score_image   0.947
NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin) (294 aa)
        score_image score_image score_image   0.946
RUVBL1
RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation (456 aa)
        score_image score_image     0.945
CENPN
centromere protein N (353 aa)
          score_image score_image   0.943
MIS18BP1
MIS18 binding protein 1; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (1132 aa)
      score_image   score_image score_image   0.935
CENPO
centromere protein O; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (300 aa)
      score_image   score_image score_image   0.924
CENPP
centromere protein P; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (288 aa)
      score_image   score_image score_image   0.916
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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