Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | C11orf70 | chromosome 11 open reading frame 70 (267 aa) | ||||||||||||
Predicted Functional Partners:
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 | C3orf18 | chromosome 3 open reading frame 18 (162 aa) |
 |
0.596 | ||||||||||
 | CCDC111 | coiled-coil domain containing 111 (560 aa) |
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0.593 | ||||||||||
 | SNX22 | sorting nexin 22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (193 aa) |
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0.591 | ||||||||||
 | CEP128 | centrosomal protein 128kDa (1094 aa) |
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0.510 | ||||||||||
 | KIAA1377 | KIAA1377 (1117 aa) |
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0.504 | ||||||||||
 | FAM134B | family with sequence similarity 134, member B; Required for long-term survival of nociceptive and autonomic ganglion neurons (497 aa) |
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0.485 | ||||||||||
 | MS4A13 | membrane-spanning 4-domains, subfamily A, member 13; May be involved in signal transduction as a component of a multimeric receptor complex (By similarity) (152 aa) |
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0.472 | ||||||||||
 | C1orf189 | chromosome 1 open reading frame 189 (101 aa) |
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0.472 | ||||||||||
 | LRRIQ1 | leucine-rich repeats and IQ motif containing 1 (1722 aa) |
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0.418 | ||||||||||
 | ANGPTL5 | angiopoietin-like 5 (388 aa) |
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0.406 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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