WBP1L protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

WBP1L

WW domain binding protein 1-like (363 aa)

Predicted Functional Partners:

CSMD1

0.700

ZNF804A

0.636

CACNA1C

0.539

C2orf82

0.504

CALHM2

0.502

UBC

0.483

PPP2R2D

0.472

CALHM3

0.472

AS3MT

0.416

CYP11A1

0.410

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AS3MT	C2orf82	ENSP00000358896	ENSP00000333208	arsenic (+3 oxidation state) methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity)	chromosome 2 open reading frame 82	0.407
AS3MT	WBP1L	ENSP00000358896	ENSP00000414721	arsenic (+3 oxidation state) methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity)	WW domain binding protein 1-like	0.416
C2orf82	AS3MT	ENSP00000333208	ENSP00000358896	chromosome 2 open reading frame 82	arsenic (+3 oxidation state) methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity)	0.407
C2orf82	WBP1L	ENSP00000333208	ENSP00000414721	chromosome 2 open reading frame 82	WW domain binding protein 1-like	0.504
CACNA1C	CSMD1	ENSP00000266376	ENSP00000441462	calcium channel, voltage-dependent, L type, alpha 1C subunit	CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas	0.496
CACNA1C	UBC	ENSP00000266376	ENSP00000344818	calcium channel, voltage-dependent, L type, alpha 1C subunit	ubiquitin C	0.775
CACNA1C	WBP1L	ENSP00000266376	ENSP00000414721	calcium channel, voltage-dependent, L type, alpha 1C subunit	WW domain binding protein 1-like	0.539
CACNA1C	ZNF804A	ENSP00000266376	ENSP00000303252	calcium channel, voltage-dependent, L type, alpha 1C subunit	zinc finger protein 804A	0.648
CALHM2	WBP1L	ENSP00000260743	ENSP00000414721	calcium homeostasis modulator 2; Pore-forming subunit of a voltage-gated ion channel (By similarity)	WW domain binding protein 1-like	0.502
CALHM3	WBP1L	ENSP00000358798	ENSP00000414721	calcium homeostasis modulator 3; Pore-forming subunit of a voltage-gated ion channel (By similarity)	WW domain binding protein 1-like	0.472
CSMD1	CACNA1C	ENSP00000441462	ENSP00000266376	CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.496
CSMD1	WBP1L	ENSP00000441462	ENSP00000414721	CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas	WW domain binding protein 1-like	0.700
CSMD1	ZNF804A	ENSP00000441462	ENSP00000303252	CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas	zinc finger protein 804A	0.703
CYP11A1	WBP1L	ENSP00000268053	ENSP00000414721	cytochrome P450, family 11, subfamily A, polypeptide 1; Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone	WW domain binding protein 1-like	0.410
PPP2R2D	WBP1L	ENSP00000399970	ENSP00000414721	protein phosphatase 2, regulatory subunit B, delta; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle- the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of t [...]	WW domain binding protein 1-like	0.472
UBC	CACNA1C	ENSP00000344818	ENSP00000266376	ubiquitin C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.775
UBC	WBP1L	ENSP00000344818	ENSP00000414721	ubiquitin C	WW domain binding protein 1-like	0.483
WBP1L	AS3MT	ENSP00000414721	ENSP00000358896	WW domain binding protein 1-like	arsenic (+3 oxidation state) methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity)	0.416
WBP1L	C2orf82	ENSP00000414721	ENSP00000333208	WW domain binding protein 1-like	chromosome 2 open reading frame 82	0.504
WBP1L	CACNA1C	ENSP00000414721	ENSP00000266376	WW domain binding protein 1-like	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.539

page 1 of 2

Experiments

Cooccurrence

Textmining

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About