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STRINGSTRING
ENSG00000259024 ENSG00000259024 FAM18A FAM18A LRCH2 LRCH2 TMEM64 TMEM64 FBXO8 FBXO8 SMARCD1 SMARCD1 LRCH1 LRCH1 FAM18B1 FAM18B1 UBC UBC FUBP3 FUBP3 KPNA3 KPNA3
"TMEM64" - transmembrane protein 64 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM64transmembrane protein 64 (380 aa)    
Predicted Functional Partners:
LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1 (763 aa)
            score_image   0.659
FBXO8
F-box protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential) (319 aa)
            score_image   0.636
FUBP3
far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression (572 aa)
            score_image   0.573
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1; Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subuni [...] (515 aa)
            score_image   0.529
KPNA3
karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] (521 aa)
            score_image   0.522
LRCH2
leucine-rich repeats and calponin homology (CH) domain containing 2 (765 aa)
            score_image   0.514
UBC
ubiquitin C (685 aa)
        score_image       0.500
ENSG00000259024
FAM18B2-CDRT4 readthrough (164 aa)
            score_image   0.491
FAM18B1
family with sequence similarity 18, member B1 (205 aa)
            score_image   0.491
FAM18A
family with sequence similarity 18, member A (213 aa)
            score_image   0.491
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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