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TBP TBP TBPL1 TBPL1 CEP72 CEP72 TBPL2 TBPL2 SPATA24 SPATA24 CACNG6 CACNG6 OR4D2 OR4D2 FAM71A FAM71A LRRC43 LRRC43 TSPO2 TSPO2 ASB16 ASB16
"SPATA24" - spermatogenesis associated 24 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
SPATA24spermatogenesis associated 24; Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box- containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity) (205 aa)    
Predicted Functional Partners:
TBPL1
TBP-like 1; Does not bind the TATA box. Has DNA-binding ability (186 aa)
        score_image   score_image   0.816
FAM71A
family with sequence similarity 71, member A (594 aa)
            score_image   0.586
TBP
TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...] (339 aa)
        score_image   score_image   0.569
TBPL2
TATA box binding protein like 2; Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity) (375 aa)
        score_image   score_image   0.551
LRRC43
leucine rich repeat containing 43 (656 aa)
            score_image   0.516
CACNG6
calcium channel, voltage-dependent, gamma subunit 6; Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity) (260 aa)
            score_image   0.512
ASB16
ankyrin repeat and SOCS box containing 16; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (453 aa)
            score_image   0.479
CEP72
centrosomal protein 72kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (647 aa)
        score_image       0.475
OR4D2
olfactory receptor, family 4, subfamily D, member 2; Odorant receptor (Potential) (307 aa)
            score_image   0.470
TSPO2
translocator protein 2; Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocyte maturation (170 aa)
            score_image   0.414
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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