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SLC30A6 SLC30A6 SLC30A8 SLC30A8 KIF11 KIF11 FTO FTO CDKAL1 CDKAL1 TCF7L2 TCF7L2 WFS1 WFS1 HHEX HHEX IGF2BP2 IGF2BP2 KCNJ11 KCNJ11 MTNR1B MTNR1B
"SLC30A8" - solute carrier family 30 (zinc transporter), member 8 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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SLC30A8solute carrier family 30 (zinc transporter), member 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells (369 aa)    
Predicted Functional Partners:
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1; Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine (579 aa)
            score_image   0.938
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2; Binds to the 5’-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs (599 aa)
            score_image   0.878
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box) (602 aa)
            score_image   0.871
SLC30A6
solute carrier family 30 (zinc transporter), member 6; Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment (By similarity) (501 aa)
            score_image   0.826
HHEX
hematopoietically expressed homeobox; Recognizes the DNA sequence 5’-ATTAA-3’. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity) (270 aa)
            score_image   0.818
FTO
fat mass and obesity associated; Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and ener [...] (505 aa)
            score_image   0.815
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity) [...] (390 aa)
            score_image   0.772
MTNR1B
melatonin receptor 1B; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity (362 aa)
            score_image   0.755
KIF11
kinesin family member 11; Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays (1056 aa)
      score_image     score_image   0.745
WFS1
Wolfram syndrome 1 (wolframin); Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (890 aa)
            score_image   0.729
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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