Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TMEM171 | transmembrane protein 171 (324 aa) | ||||||||||||
Predicted Functional Partners:
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 | UBE2Q2 | ubiquitin-conjugating enzyme E2Q family member 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination (375 aa) |
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0.633 | ||||||||||
 | MIER1 | mesoderm induction early response 1 homolog (Xenopus laevis) (565 aa) |
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0.613 | ||||||||||
 | BAZ1B | bromodomain adjacent to zinc finger domain, 1B (1483 aa) |
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0.567 | ||||||||||
 | HNF4G | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha (445 aa) |
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0.566 | ||||||||||
 | B3GNT4 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 4; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides (378 aa) |
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0.531 | ||||||||||
 | TRIM46 | tripartite motif containing 46 (759 aa) |
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0.510 | ||||||||||
 | SLC16A9 | solute carrier family 16, member 9 (monocarboxylic acid transporter 9); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity) (509 aa) |
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0.499 | ||||||||||
 | SFMBT1 | Scm-like with four mbt domains 1 (866 aa) |
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0.499 | ||||||||||
 | A1CF | APOBEC1 complementation factor (594 aa) |
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0.420 | ||||||||||
 | ATXN2 | ataxin 2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane (1313 aa) |
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0.414 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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