node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH3A1 | PIGG | ENSP00000225740 | ENSP00000415203 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | phosphatidylinositol glycan anchor biosynthesis, class G | 0.885 |
ALDH3A2 | PIGG | ENSP00000345774 | ENSP00000415203 | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | phosphatidylinositol glycan anchor biosynthesis, class G | 0.889 |
ARV1 | PIGG | ENSP00000312458 | ENSP00000415203 | ARV1 homolog (S. cerevisiae) | phosphatidylinositol glycan anchor biosynthesis, class G | 0.820 |
ARV1 | PIGO | ENSP00000312458 | ENSP00000339382 | ARV1 homolog (S. cerevisiae) | phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity) | 0.557 |
PIGB | PIGF | ENSP00000164305 | ENSP00000281382 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | 0.971 |
PIGB | PIGG | ENSP00000164305 | ENSP00000415203 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class G | 0.724 |
PIGB | PIGH | ENSP00000164305 | ENSP00000216452 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | 0.642 |
PIGB | PIGK | ENSP00000164305 | ENSP00000359848 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class K; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein | 0.680 |
PIGB | PIGO | ENSP00000164305 | ENSP00000339382 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity) | 0.969 |
PIGB | TMED10 | ENSP00000164305 | ENSP00000303145 | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] | 0.726 |
PIGF | PIGB | ENSP00000281382 | ENSP00000164305 | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | 0.971 |
PIGF | PIGG | ENSP00000281382 | ENSP00000415203 | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | phosphatidylinositol glycan anchor biosynthesis, class G | 0.986 |
PIGF | PIGH | ENSP00000281382 | ENSP00000216452 | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | phosphatidylinositol glycan anchor biosynthesis, class H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | 0.803 |
PIGF | PIGK | ENSP00000281382 | ENSP00000359848 | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | phosphatidylinositol glycan anchor biosynthesis, class K; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein’s C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein | 0.923 |
PIGF | PIGO | ENSP00000281382 | ENSP00000339382 | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity) | 0.986 |
PIGG | ALDH3A1 | ENSP00000415203 | ENSP00000225740 | phosphatidylinositol glycan anchor biosynthesis, class G | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | 0.885 |
PIGG | ALDH3A2 | ENSP00000415203 | ENSP00000345774 | phosphatidylinositol glycan anchor biosynthesis, class G | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.889 |
PIGG | ARV1 | ENSP00000415203 | ENSP00000312458 | phosphatidylinositol glycan anchor biosynthesis, class G | ARV1 homolog (S. cerevisiae) | 0.820 |
PIGG | PIGB | ENSP00000415203 | ENSP00000164305 | phosphatidylinositol glycan anchor biosynthesis, class G | phosphatidylinositol glycan anchor biosynthesis, class B; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly | 0.724 |
PIGG | PIGF | ENSP00000415203 | ENSP00000281382 | phosphatidylinositol glycan anchor biosynthesis, class G | phosphatidylinositol glycan anchor biosynthesis, class F; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI (By similarity) | 0.986 |