Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | IGFL1 | IGF-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor (110 aa) | ||||||||||||
Predicted Functional Partners:
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 | IGFLR1 | IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2 (355 aa) |
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0.710 | |||||||||
 | C10orf99 | chromosome 10 open reading frame 99 (81 aa) |
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0.644 | ||||||||||
 | C22orf42 | chromosome 22 open reading frame 42 (251 aa) |
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0.583 | ||||||||||
 | GLT6D1 | glycosyltransferase 6 domain containing 1 (276 aa) |
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0.564 | ||||||||||
 | GEMIN8 | gem (nuclear organelle) associated protein 8; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus (242 aa) |
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0.472 | ||||||||||
 | SPINK6 | serine peptidase inhibitor, Kazal type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8 (80 aa) |
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0.407 | ||||||||||
 | PLEKHA6 | pleckstrin homology domain containing, family A member 6 (1048 aa) |
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0.405 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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